Skip to Content
MilliporeSigma

C5424

Conduritol B epoxide

powder, ≥95% (TLC)

Synonym(s):

1,2-Anhydro-myo-inositol

Slide 1 of 1
Sign In to View Organizational & Contract Pricing.

Select a Size

5 MG

$187.00

25 MG

$638.00

$187.00

Available to ship TODAYDetails

Request a Bulk Order

About This Item

CAS Number:
6090-95-5
UNSPSC Code:
12352119
PubChem Substance ID:
24892783
NACRES:
NA.32
MDL number:
MFCD00077326

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Conduritol B epoxide,

SMILES string

OC1C(O)C(O)C2OC2C1O

InChI

1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H

InChI key

ZHMWOVGZCINIHW-UHFFFAOYSA-N

biological source

synthetic (organic)

assay

≥95% (TLC)

form

powder

solubility

water: 20 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

Quality Level

100

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
234599C951057570
Conduritol B epoxide

Sigma-Aldrich

C5424

Conduritol B epoxide

Conduritol B Epoxide Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.

Sigma-Aldrich

234599

Conduritol B Epoxide

Pyrocatechol ≥99%

Sigma-Aldrich

C9510

Pyrocatechol

myo-Inositol ≥99.0%, suitable for microbiology

Millipore

57570

myo-Inositol

assay

≥95% (TLC)

assay

≥98% (HPLC)

assay

≥99%

assay

≥99.0% (HPLC)

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

solid

form

powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

-

solubility

water: 20 mg/mL, clear, colorless to faintly yellow

solubility

DMSO: soluble, water: soluble

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 0.1 g/mL, clear

General description

Conduritol B epoxide (CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.[1]

Application

Conduritol B epoxide has been used as an inhibitor of GBA1 to discriminate between acid β-glucosidase (GBA1) and non-lysosomal β-glucosidase (GBA2) activity in β-glucosidase activity assay.[2] It has also been used as a selective glucocerebrosidase (GCase) inhibitor.[3]

Biochem/physiol Actions

β-Glucosidase inhibitor
Conduritol B epoxide (CBE) is capable of inactivating sucrase-isomaltase irreversibly.[1] It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).[4]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKDB0997
MKCZ1921
MKCW3816
MKCW9869
MKCS7178

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling
Kuo CL, et al.
FEBS Journal, 286(3), 584-600 (2019)
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity
Farfel-BT, et al.
Cell Reports, 28(1), 51-64 (2019)
Stereospecific ring opening of conduritol-B-epoxide by an active site aspartate residue of sucrase-isomaltase
Braun H, et al.
Biochimica et Biophysica Acta, 483(1), 135-140 (1977)
S C Datta et al.
Biochemical and biophysical research communications, 152(1), 155-160 (1988-04-15)
A model of the human genetic disorder, Gaucher disease, can be rapidly generated in mice by the injection of emulsified glucosylceramide and an inhibitor of the lipid's hydrolase, conduritol B epoxide. The liver grows rapidly as it absorbs the load
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease
Schonauer S, et al.
Test, 292(15), 6177-6189 (2017)
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service