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  • C5608
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C5608

Sigma-Aldrich

Collagen from rabbit skin

Bornstein and Traub Type I, powder

CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

rabbit skin

Quality Level

description

acid soluble

form

powder

technique(s)

cell culture | stem cell: suitable

solubility

aqueous acid: ≤10 mg/mL
aqueous sodium acetate buffer: soluble (0.01-0.5M)

UniProt accession no.

storage temp.

2-8°C

Gene Information

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C7661C1188C8919
Collagen from rat tail Bornstein and Traub Type I, powder, BioReagent, suitable for cell culture

Sigma-Aldrich

C7661

Collagen from rat tail

biological source

rabbit skin

biological source

rat tail

biological source

bovine cartilage (tracheal)

biological source

bovine (calf) skin

form

powder

form

powder

form

powder

form

solution (0.1% solution in 0.1 M acetic acid)

technique(s)

cell culture | stem cell: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

solubility

aqueous acid: ≤10 mg/mL, aqueous sodium acetate buffer: soluble (0.01-0.5M)

solubility

soluble (Product is clear to hazy colorless solution with a few insolubles at 1 mg/ml in water with 2 μl acetic acid (or 0.1 N acetic acid). The insolubles can be removed by settling or centrifugation.)

solubility

aqueous acid: soluble

solubility

-

UniProt accession no.

Q28668

UniProt accession no.

P02454

UniProt accession no.

P02459

UniProt accession no.

P02453, P02459

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen-type 1 may be used in research of Idiopathic pulmonary fibrosis (IPF). Robust expression of collagen-type 1 is one distinctive feature of IPF. Additionally, collagen-type 1 has been used in studies on the effect of endoplasmic reticulum (ER) stress from IPF on myofibroblastic differentiation of lung fibroblasts. Collage-type 1 soluble in acidic solution produces three dimensional scaffolding useful in bioengineering and cell culture applications where biomaterials are needed to replace native collagen extracellular matrices.

Collagen Type I has been used as a scaffold for the growth in vitro of stem cells in a wide variety of biomaterial engineering studies.

Preparation Note

Prepared with modification of Gallop, P.M.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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