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C5679

Sigma-Aldrich

Casein from bovine milk

BioReagent, suitable for insect cell culture

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CAS Number:
EC Number:
MDL number:
NACRES:
NA.75

biological source

bovine milk

Quality Level

product line

BioReagent

form

powder

technique(s)

cell culture | insect: suitable

mp

280 °C (dec.) (lit.)

UniProt accession no.

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

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This Item
C6554C5890C0406
Casein from bovine milk BioReagent, suitable for insect cell culture

C5679

Casein from bovine milk

Casein from bovine milk BioReagent, suitable for insect cell culture

C6554

Casein from bovine milk

Casein from bovine milk suitable for substrate for protein kinase (after dephosphorylation), purified powder

C5890

Casein from bovine milk

κ-Casein from bovine milk ≥70% (PAGE), lyophilized powder

C0406

κ-Casein from bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

form

powder

form

powder

form

purified powder

form

lyophilized powder

Gene Information

bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728)

Gene Information

bovine ... CSN2(281099), CSN3(281728)

Gene Information

bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728)

Gene Information

cow ... MKCAS(100531419), MKCASP(105755569)

UniProt accession no.

P02662, P02666, P02663, P02668

UniProt accession no.

P02666, P02668

UniProt accession no.

P02662, P02663, P02666, P02668

UniProt accession no.

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

Casein is a calcium phosphate-binding phosphoprotein present in mammalian milk. It constitutes about 80% of the total bovine milk. Bovine milk is made of four types of casein such as, αs1-, αs2-, β-, and κ-caseins.

Application

Casein from bovine milk has been used as a component of normal medium for Drosophila culture , in the preparation of αS1-casein (CAS1_Bovin) , as a source of nitrogen (N) in experiment diets .

Biochem/physiol Actions

Partial gastrointestinal digestion of casein is a rich source of bioactive peptides, such as β-casomorphin. However, bovine casein is not homogeneous; variants A1 and B do lead to production of β-casomorphin 7 production, while A2 does not.
Numerous experimental applications including use as a blocking agent in immunochemistry, recovery of enzyme activity from SDS extracted samples, and as a substrate for protease and kinase assays.

Quality

essentially vitamin free

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)


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Potential of casein as a carrier for biologically active agents
Glkab T K and Boratynski J
Topics in Current Chemistry, 375(4), 71-71 (2017)
The effects of rumen nitrogen balance on in vitro rumen fermentation and microbial protein synthesis vary with dietary carbohydrate and nitrogen sources
Kand D, et al.
Anim. Feed Sci. Technol., 241(12) (2018)
Casein and Peptides Derived from Casein as Antileukaemic Agents
Ledesma M E, et al.
Journal of Oncology, 2019(4), 71-71 (2019)
T cell recognition pattern of bovine milk alphaS1-casein and its peptides
Elsayed S, et al.
Molecular Immunology, 41(12) (2004)
S Elsayed et al.
Molecular immunology, 41(12), 1225-1234 (2004-10-16)
T cell recognition patterns of CAS1_Bovin, its limited hydrolysis, oxidized, reduced/alkylated, cyanogen bromide cleavage fractions and synthetic peptides were examined. Thirteen overlapping peptides covering the intact molecule, with chain lengths varied between 17 and 20 AA, were prepared by f-moc

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