C5762

Sigma-Aldrich

Colominic acid sodium salt from Escherichia coli

Synonym(s):
Poly[2,8-(N-acetylneuraminic acid sodium salt)]
Linear Formula:
(C11H16NNaO8)n
CAS Number:
MDL number:

form

powder

Quality Level

solubility

H2O: 50 mg/mL

Mode of action

enzyme | inhibits

antibiotic activity spectrum

viruses

storage temp.

−20°C

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Application

Colominic acid is used to study protein polysialylation processes. It is a substrate for CMP-NeuAc:(NeuAcα2→8)n (colominic acid) sialyltransferase.

Packaging

100 mg in poly bottle
1 g in poly bottle

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

J Roth et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(9), 2999-3003 (1988-05-01)
A unique structural feature of the neural cell adhesion molecule N-CAM is the presence of homopolymers of alpha (2----8)-linked sialic acid units. We have used two specific probes for the detection of poly(sialic acid) in normal human kidney and Wilms...
J Roth et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(7), 1969-1973 (1987-04-01)
We report the presence of alpha(2----8)-linked polysialic acid as detected with a monoclonal antibody outside the nervous tissue in the postnatal developing rat kidney. By immunoblot analysis, the reactivity was confined to a broad band of apparent molecular mass 200-250...
J Finne et al.
Journal of immunology (Baltimore, Md. : 1950), 138(12), 4402-4407 (1987-06-15)
The structurally similar polysialic acid capsules of group B meningococci and Escherichia coli K1 are poor immunogens, and attempts are currently being made to improve their immunogenicity by chemical modifications. An IgG monoclonal antibody to these polysialic acid capsules was...
Nina Westphal et al.
Scientific reports, 7(1), 13631-13631 (2017-10-21)
The neural cell adhesion molecule (NCAM) is the major carrier of polysialic acid (PSA) which modulates NCAM functions of neural cells at the cell surface. In previous studies, we have shown that stimulation of cultured neurons with surrogate NCAM ligands...
Articles
Review article and products for sialic acid synthesis and signaling.
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