C5776

Cocaine hydrochloride

• Synonym(s): Ecgonine methyl ester benzoate hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₂₁NO₄ · HCl
• CAS Number: 53-21-4
• Molecular Weight: 339.81
• EC Number: 200-167-1
• MDL number: MFCD00058119
• PubChem Substance ID: 329775099
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• drug control: USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
• application(s): forensics and toxicology
• SMILES string: Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
• InChI: 1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
• InChI key: PIQVDUKEQYOJNR-VZXSFKIWSA-N

Description

Application

Cocaine hydrochloride has been used:

• in saline control to study the effects of cocaine self-administration in mouse brain
• as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)
• to examine conditioning to intravenous cocaine hydrochloride

Packaging

1, 5, 10 g

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 + H330 - H336 - H361d
• Precautionary Statements: P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves