C6499

CTB

≥98% (HPLC)

• Synonym(s): CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide
• Empirical Formula (Hill Notation): C₁₆H₁₃ClF₃NO₂
• CAS Number: 451491-47-7
• Molecular Weight: 343.73
• MDL number: MFCD02356522
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• Storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
• InChI key: YDXZSNHARVUYNM-UHFFFAOYSA-N

Description

General description

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.[1]

Application

CTB has been used to study its apoptotic effects on P53 protein acetylation.[2]

Biochem/physiol Actions

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.

CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.

Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.[1]

Features and Benefits

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2