C6637

Sigma-Aldrich

Cytochalasin A from Drechslera dematioidea

Empirical Formula (Hill Notation):
C29H35NO5
CAS Number:
Molecular Weight:
477.59
Beilstein/REAXYS Number:
949521
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

storage temp.

−20°C

SMILES string

C[C@@H]1CCCC(=O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O

InChI

1S/C29H35NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,23-24,26-27,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,23+,24+,26+,27-,29-/m1/s1

InChI key

ZMAODHOXRBLOQO-TZVKRXPSSA-N

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Packaging

1 mg in glass bottle

Biochem/physiol Actions

Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.

Other Notes

Oxidized analog of cytochalasin B.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T+

Risk Statement

63-26/27/28

Safety Statement

28-36/37-45

RIDADR

UN 1544PSN1 6.1 / PGII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Tehila Hyman et al.
Molecular biology of the cell, 17(1), 427-437 (2005-10-28)
In epithelial cell lines, apical but not basolateral clathrin-mediated endocytosis has been shown to be affected by actin-disrupting drugs. Using electron and fluorescence microscopy, as well as biochemical assays, we show that the amount of actin dedicated to endocytosis is...
Yujiro Higuchi et al.
Biochemical and biophysical research communications, 340(3), 784-791 (2005-12-29)
Endocytosis is an important process for cellular activities. However, in filamentous fungi, the existence of endocytosis has been so far elusive. In this study, we used AoUapC-EGFP, the fusion protein of a putative uric acid-xanthine permease with enhanced green fluorescent...
Kumiko Masai et al.
Bioscience, biotechnology, and biochemistry, 68(7), 1569-1573 (2004-07-28)
The distribution of the secreted protein ribonuclease T1 (RntA) fused with the enhanced green fluorescent protein (EGFP), RntA-EGFP, was visualized in hyphae of Aspergillus oryzae in the presence of a protein transport inhibitor, brefeldin A, cytochalasin A, or nocodazole. During...
Naimeh Taheri-Talesh et al.
Molecular biology of the cell, 19(4), 1439-1449 (2008-01-25)
Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of...
J Adrian Lunn et al.
The Journal of biological chemistry, 282(14), 10370-10379 (2007-02-10)
The results presented here demonstrate that focal adhesion kinase (FAK) Tyr-861 is the predominant tyrosine phosphorylation site stimulated by hyperosmotic stress in a variety of cell types, including epithelial cell lines (ileum-derived IEC-18, colon-derived Caco2, and stomach-derived NCI-N87), FAK null...

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