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C6780

Sigma-Aldrich

α-Casein from bovine milk

≥70% αs-casein basis (electrophoresis), lyophilized powder

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Synonym(s):
alpha-S1-casein, alpha-S2-casein
CAS Number:
EC Number:
MDL number:

biological source

bovine milk

Quality Level

assay

≥70% αs-casein basis (electrophoresis)

form

lyophilized powder

technique(s)

mass spectrometry (MS): suitable

UniProt accession no.

storage temp.

−20°C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

Gene Information

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This Item
C6905C9801SRE0081
vibrant-m

C6780

α-Casein from bovine milk

vibrant-m

C6905

β-Casein from bovine milk

vibrant-m

SRE0081

CaseiNSBlock

technique(s)

mass spectrometry (MS): suitable

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

technique(s)

enzyme immunoassay: suitable

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

400

Gene Information

cow ... CSN1(282208), CSN1S2(282209)

Gene Information

bovine ... CSN2(281099), CSN3(281728)

Gene Information

bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728)

Gene Information

bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Application

α-Casein from bovine milk is an Immunoglobulin E (IgE)-binding epitope belonging to the Casein phosphoprotein family. It has been used in studies of children with insulin-dependent diabetes mellitus (IDDM), due to the strong cross-reactivity of α-casein antibodies with insulin. Studies of children displaying (IDDM) show higher levels of α-casein antibodies than control siblings, which may serve as a risk marker for IDDM.

Biochem/physiol Actions

α-Casein can be an immunogen in young children, and anti-a-casein antibodies have strong cross-reactivity with insulin. This effect can explain the uncommon insulin autoimmunity, but it does not appear to progress to Type I diabetes.

Preparation Note

Chromatographically purified

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)


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Articles

-casein basis (electrophoresis), lyophilized powder; β-Casein from bovine milk, BioUltra, ≥98% (PAGE)

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