T Chiba et al.
Allergy, 67(7), 936-942 (2012-05-16)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which regulate not only adipogenesis and proliferation/differentiation but also the immune response of cells. Because topical application of the activators of some PPAR isoforms improved clinical symptoms in patients with atopic dermatitis (AD)...
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-alpha, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Yang R, et al.
Pharmacology, Biochemistry, and Behavior, 153, 97-104 (2017)
PPAR-alpha activation mediates innate host defense through induction of TFEB and lipid catabolism
Kim YS, et al.
Journal of Immunology, 198(8), 3283-3295 (2017)
Andrew D Patterson et al.
Hepatology (Baltimore, Md.), 56(1), 281-290 (2012-02-10)
Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis. Activation of the peroxisome proliferator-activated receptor alpha (PPARα), a member...
Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) alphagamma
Moldes-Anaya A, et al.
Marine drugs, 15(6), 148-148 (2017)