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C8138

Sigma-Aldrich

Chlorpromazine hydrochloride

≥98% (TLC)

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Synonym(s):
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil
Empirical Formula (Hill Notation):
C17H19ClN2S · HCl
CAS Number:
Molecular Weight:
355.33
Beilstein/REAXYS Number:
3779989
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (TLC)

form

powder

mp

194-196 °C

solubility

water: 50 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

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1 of 4

This Item
C0982P465131679
vibrant-m

C8138

Chlorpromazine hydrochloride

vibrant-m

C0982

Chlorpromazine hydrochloride

vibrant-m

P4651

Promethazine hydrochloride

vibrant-m

31679

Chlorpromazine hydrochloride

assay

≥98% (TLC)

assay

98.0-101.5% dry basis

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

water: 50 mg/mL

solubility

water: soluble 50 g/L

solubility

-

solubility

-

originator

GlaxoSmithKline

originator

-

originator

Wyeth

originator

-

mp

194-196 °C

mp

194-196  °C

mp

-

mp

-

Application

Chlorpromazine hydrochloride has been used:
  • as an antagonists for calmodulin kinase
  • as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
  • as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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