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C8742

Sigma-Aldrich

CHIC-35

≥97% (chiral, HPLC)

Synonym(s):
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35
Empirical Formula (Hill Notation):
C14H15ClN2O
CAS Number:
Molecular Weight:
262.73
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥97% (chiral, HPLC)

form

solid

solubility

DMSO: >10 mg/mL
H2O: <2 mg/mL

storage temp.

2-8°C

SMILES string

ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1

InChI

1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1

InChI key

ABIVOOWWGYJNLV-JTQLQIEISA-N

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This Item
SML1094SML3054SML3092
CHIC-35 &#8805;97% (chiral, HPLC)

Sigma-Aldrich

C8742

CHIC-35

CHIR 98014 &#8805;98% (HPLC)

Sigma-Aldrich

SML1094

CHIR 98014

CHIR124 &#8805;98% (HPLC)

Sigma-Aldrich

SML3054

CHIR124

CHIR-090 &#8805;98% (HPLC)

Sigma-Aldrich

SML3092

CHIR-090

form

solid

form

powder

form

powder

form

powder

solubility

DMSO: >10 mg/mL, H2O: <2 mg/mL

solubility

DMSO: 0.5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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