C8742

CHIC-35

Name: CHIC-35
Brand: SIGMA
Price: 175.1 USD
Availability: InStock

≥97% (chiral, HPLC)

Synonym(s):

(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₅ClN₂O

CAS Number:

848193-72-6

Molecular Weight:

262.73

MDL number:

MFCD11045286

UNSPSC Code:

12352200

PubChem Substance ID:

329775186

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥97% (chiral, HPLC)

form

solid

solubility

DMSO: >10 mg/mL
H₂O: <2 mg/mL

storage temp.

2-8°C

SMILES string

ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1

InChI

1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1

InChI key

ABIVOOWWGYJNLV-JTQLQIEISA-N

Related Categories

Bioactive Small Molecule Inhibitors

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This Item	566325	B5435	614310
Sigma-Aldrich C8742 CHIC-35	Sigma-Aldrich 566325 SIRT1 Inhibitor IV, (S)-35	Sigma-Aldrich B5435 BIA 2-093	Sigma-Aldrich 614310 TLR3/dsRNA Complex Inhibitor
assay ≥97% (chiral, HPLC)	assay ≥96% (HPLC)	assay ≥98% (HPLC)	assay ≥99% (HPLC)
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >10 mg/mL, H₂O: <2 mg/mL	solubility DMSO: 10 mg/mL, ethanol: 5 mg/mL	solubility DMSO: ~21 mg/mL, H₂O: insoluble	solubility DMSO: 50 mg/mL

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1.

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC₅₀ of S-isomer is 60 nM; IC₅₀ of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC₅₀ for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

087K46342

087K46341

087K4634

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CHIC-35