MilliporeSigma
  • C8754
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C8754

Sigma-Aldrich

Thiamine pyrophosphate

≥95%

Synonym(s):
Aneurinepyrophosphoric acid, Cocarboxylase, Thiamine pyrophosphate chloride
Empirical Formula (Hill Notation):
C12H19ClN4O7P2S
CAS Number:
Molecular Weight:
460.77
Beilstein:
3875902
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.54

Quality Level

Assay

≥95%

form

powder

solubility

H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

SMILES string

CC1=C(CCOP(OP(O)(O)=O)(O)=O)SC=[N+]1CC2=C(N)N=C(C)N=C2.[Cl-]

InChI

1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H

InChI key

YXVCLPJQTZXJLH-UHFFFAOYSA-N

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This Item
PHR1369P0049T1270
Thiamine pyrophosphate ≥95%

Sigma-Aldrich

C8754

Thiamine pyrophosphate

Thiamine pyrophosphate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1369

Thiamine pyrophosphate

Thiamine hydrochloride BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sigma-Aldrich

T1270

Thiamine hydrochloride

assay

≥95%

assay

-

assay

-

assay

≥99.0% (HPLC)

form

powder

form

-

form

solid

form

powder

solubility

H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless

solubility

-

solubility

-

solubility

H2O: 50 mg/mL, clear, colorless

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

-

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

200

Application

Thiamine pyrophosphate from Sigma has been used as a substrate to assay the enzymes in golgi lamellae isolated from rat tissue.
Thiamine pyrophosphate has been used:
  • for the preparation of chitosan nano-particles
  • as a standard for vitamin B1 and its derivative in high-performance
  • liquid chromatography (HPLC) analysis
  • immunofluorescence

Biochem/physiol Actions

Thiamine pyrophosphate (TPP) is a coenzyme of transketolase, that catalyzes the cleavage of ribulose-5-phosphate. This reaction leads to the formation of D-glyceraldehyde-3-phosphate. It requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde. TPP is capable of decarboxylating hydroxypyruvate in the presence of an ′acceptor aldehyde′.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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