C8990

Sigma-Aldrich

Sp-8-pCPT-cAMPS

≥98% (HPLC), solid

Synonym(s):
8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt
Empirical Formula (Hill Notation):
C16H14ClN5O5PS2Na
CAS Number:
Molecular Weight:
509.86
MDL number:
PubChem Substance ID:

assay

≥98% (HPLC)

form

solid

packaging

vial of 5 μmol

solubility

H2O: >1 mg/mL

shipped in

dry ice

storage temp.

−70°C

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

General description

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.

Application

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.

Biochem/physiol Actions

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.
Selective cAMP-dependent protein kinase (PKA) activator.

Certificate of Analysis

Certificate of Origin

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