C9755

Sigma-Aldrich

Cytidine 5′-diphosphate sodium salt hydrate

from yeast, ≥95%

Synonym(s):
CDP sodium salt hydrate
Empirical Formula (Hill Notation):
C9H15N3O11P2
Molecular Weight:
403.18
MDL number:
PubChem Substance ID:
NACRES:
NA.51

Quality Level

biological source

yeast

assay

≥95%

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)N(C=C1)C2OC(COP(O)(=O)OP(O)(O)=O)C(O)C2O

InChI

1S/C9H15N3O11P2.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18);;

InChI key

MAGSIBHRUIBONY-UHFFFAOYSA-N

General description

Cytidine 5′-diphosphate (CDP) is synthesized from cytidine monophosphate (CMP) or uridine monophosphate (UMP) by the transfer of phosphoryl group, catalyzed by the enzyme uridylate kinase (UMPK). CTP synthetase catalyzes the conversion of CTP to CDP intermediates like CDP-diacylglycerol, CDP-choline and CDP-ethanolamine for phospholipid biosynthesis.

Application

Cytidine 5′-diphosphate sodium salt hydrate has been used:
  • as a substrate in nucleoside diphosphatase (NDPase) enzyme histochemistry assay of gold fish eye sections
  • in ribonucleotide reductase assay
  • dCDP formation assay.

Packaging

25, 100 mg in poly bottle

Biochem/physiol Actions

Cytidine 5′-diphosphate (CDP) is used as a substrate of nucleoside diphosphatase kinase to produce CTP for supporting DNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Certificate of Analysis
Certificate of Origin
Microglial cells in the retina of Carassius auratus: effects of optic nerve crush
Salvador-Silva M, et al.
The Journal of Comparative Neurology, 417(4), 431-447 (2000)
Yan Zhang et al.
Biochemistry, 50(25), 5615-5623 (2011-05-13)
Bacillus subtilis class Ib ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to deoxynucleotides, providing the building blocks for DNA replication and repair. It is composed of two proteins: α (NrdE) and β (NrdF). β contains the metallo-cofactor, essential for...
Purine and pyrimidine nucleotide synthesis and metabolism
The Arabidopsis Book / American Society of Plant Biologists, 1 (2002)
CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae
Chang YF and Carman GM
Progress in Lipid Research, 47(5), 333-339 (2008)
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
Foskolou IP, et al.
Molecular Cell, 66(2), 206-220 (2017)
Protocols
ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.
Read More
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
Read More

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