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Casein, N,N-dimethylated from bovine milk

essentially salt-free, lyophilized powder

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CAS Number:
MDL number:

biological source

bovine milk

Quality Level


≥90% (colorimetric)


essentially salt-free, lyophilized powder


activity assay: suitable

UniProt accession no.

storage temp.




InChI key


General description

Casein is a milk protein, that is not expensive and nontoxic. highly stable. This phosphoproteins accounts for 80% of the total protein present in bovine milk. Casein is a member of one of the larger family of secretory calcium?binding phosphoproteins.


Casein, N,N-dimethylated from bovine milk has been used:
  • in the determination of general proteolytic activity
  • as a substrate to study the effect of dephosphorylation on the calcium-activated neutral proteases (CANP) proteolysis of paired helical filaments (PHF) II-τ
  • in transglutaminase (TG) assay

Casein, N,N-dimethylated from bovine milk can be used in assays to detect and help determine the functional role of tissue transglutaminase (tTG) in disease. In particular, Casein, N,N-dimethylated has been used in the mechanic and kinetic analysis of tTG on protein substrates, which may be linked to neurodegenerative disease.

This preparation has less than 10% reactivity with 2,4,6-trinitrobenzenesulfonic acid (TNBS) compared to non-methylated casein.

Protease substrate that has been used to assay basilase and a subtilisin analog that had been produced by site-directed mutagenesis.

Biochem/physiol Actions

Casein is highly preferred as a drug delivery vehicle. It possess antioxidant activity.

Preparation Note

Reductive methylation of C5890 by the method of Cabacungan, J.C., et al., Anal. Biochem., 124, 272 (1982).

Storage Class

11 - Combustible Solids




Not applicable


Not applicable


Eyeshields, Gloves, type N95 (US)

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Molecular effects of nicarbazin on avian reproduction
Yoder CA, et al.
Poultry Science, 85(7), 1285-1293 (2006)
Casein proteins: structural and functional aspects
Milk proteins-from structure to biological properties and health aspects. InTech, Rijeka, 1-17 (2016)
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and- 2B
Wang JZ, et al.
The Journal of Biological Chemistry, 270(9), 4854-4860 (1995)
Johannes Wolf et al.
Analytical biochemistry, 411(1), 10-15 (2010-12-15)
Tissue transglutaminase (tTG) is a calcium-dependent enzyme that exerts a variety of physiological functions and is involved in various pathoprocesses. To characterize the role of tTG in disease, simple assays are necessary for detection. We developed a highly sensitive enzyme-linked
H Grøn et al.
European journal of biochemistry, 194(3), 897-901 (1990-12-27)
The subtilisins are known to be susceptible to chemical oxidation due to the conversion of Met222 into the corresponding sulfoxide. A number of derivatives with resistance towards oxidation have previously been prepared by replacement of this group with the other

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