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  • C9801
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C9801

Sigma-Aldrich

Casein, N,N-dimethylated from bovine milk

essentially salt-free, lyophilized powder

Synonym(s):
N,N-dimethylcasein
CAS Number:
MDL number:
NACRES:
NA.61

biological source

bovine milk

Quality Level

Assay

≥90% (colorimetric)

form

essentially salt-free, lyophilized powder

technique(s)

activity assay: suitable

UniProt accession no.

storage temp.

−20°C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

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1 of 4

This Item
C5890C7906C5679
Supelco

Supelco

C7906

Casein from bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

assay

≥90% (colorimetric)

assay

-

assay

-

assay

-

form

essentially salt-free, lyophilized powder

form

purified powder

form

powder

form

powder

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable, electrophoresis: suitable, immunocytochemistry: suitable

technique(s)

photometry: suitable

technique(s)

cell culture | insect: suitable

UniProt accession no.

P02662, P02663, P02666, P02668

UniProt accession no.

P02662, P02663, P02666, P02668

UniProt accession no.

P02662, P02663, P02666, P02668

UniProt accession no.

P02662, P02663, P02666, P02668

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

General description

Casein is a milk protein, that is not expensive and nontoxic. highly stable. This phosphoproteins accounts for 80% of the total protein present in bovine milk. Casein is a member of one of the larger family of secretory calcium?binding phosphoproteins.

Application

Casein, N,N-dimethylated from bovine milk has been used:
  • in the determination of general proteolytic activity
  • as a substrate to study the effect of dephosphorylation on the calcium-activated neutral proteases (CANP) proteolysis of paired helical filaments (PHF) II-τ
  • in transglutaminase (TG) assay

Casein, N,N-dimethylated from bovine milk can be used in assays to detect and help determine the functional role of tissue transglutaminase (tTG) in disease. In particular, Casein, N,N-dimethylated has been used in the mechanic and kinetic analysis of tTG on protein substrates, which may be linked to neurodegenerative disease.

This preparation has less than 10% reactivity with 2,4,6-trinitrobenzenesulfonic acid (TNBS) compared to non-methylated casein.

Protease substrate that has been used to assay basilase and a subtilisin analog that had been produced by site-directed mutagenesis.

Biochem/physiol Actions

Casein is highly preferred as a drug delivery vehicle. It possess antioxidant activity.

Preparation Note

Reductive methylation of C5890 by the method of Cabacungan, J.C., et al., Anal. Biochem., 124, 272 (1982).

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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