Cell Line Origin
Human Caucasian lung, large cell carcinoma, drug resistant
Cell Line Description
COR-L23/5010 has been derived from the parent line, COR-L23 (Sigma Catalogue number. 92031919) by continuous exposure to increasing concentrations of doxorubicin (also known as adriamycin). The cells overexpress multidrug resistance-associated protein (MRP) and express a 190kDa membrane-protein connected to the degree of drug-resistance. COR-L23/5010 have a higher resistance than COR-L23/R (Sigma Catalogue number. 96042339).
MRP studies, drug-resistance studies
STR-PCR Data: Amelogenin: X
RPMI 1640 + 2mM Glutamine + 1.0μg/ml doxorubicin + 10% FBS
Maintain cultures between 3-9x100,000 cells/ml; 5% CO2; 37°C It is recommended to culture the cells without drug after resuscitation until the first passage.
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