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CG10

Sigma-Aldrich

Chorionic gonadotropin human

lyophilized powder, vial of ~10,000 IU

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Synonym(s):
Choriogonin, HCG
CAS Number:
MDL number:
NACRES:
NA.32

biological source

human urine

Quality Level

sterility

sterile-filtered

form

lyophilized powder

mol wt

37.9 kDa

contains

mannitol

packaging

vial of ~10,000 IU

drug control

Home Office Schedule 4.2

impurities

HBsAg, HCV and HIV-1/HIV-2, tested negative

solubility

water: 10 mL/vial, clear to slightly hazy, colorless

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CGA(1081)

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1 of 4

This Item
C1063C0434CG5
sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

drug control

Home Office Schedule 4.2

drug control

Home Office Schedule 4.2

drug control

-

drug control

Home Office Schedule 4.2

solubility

water: 10 mL/vial, clear to slightly hazy, colorless

solubility

water: 10 mL/vial, clear, colorless

solubility

water: 2 mg/mL, clear, colorless

solubility

water: 10 mL/vial, clear to slightly hazy, colorless

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

General description

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Application

Chorionic gonadotropin has been used:
  • in in vitro analysis of cytotoxicity
  • in egg and embryo preparations
  • in the superovulation of CD-1 mice
  • in gonadotropin preparations for the in vivo studies with the luteinizing hormone-releasing hormone (LHRH) agonist (LHRH-a) to synchronize naturally cycling rats.

Biochem/physiol Actions

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.

Reconstitution

When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.1 M sodium phosphate buffer (pH approx. 7.2) and 10 mg/mL of mannitol.

Analysis Note

The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 10,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggs
Johnson J, et al.
Developmental Biology, 204(2), 464-477 (1998)
Unique recombinant human ribonuclease and inhibition of Kaposi's sarcoma cell growth
Newton D L and Rybak S M
Journal of the National Cancer Institute, 90(23), 1787-1791 (1998)
Reducing inositol lipid hydrolysis, Ins (1, 4, 5) P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres.
Han J K, et al.
The Journal of Cell Biology, 116(1), 147-156 (1992)
Tammy Z Movsas et al.
Frontiers in pediatrics, 5, 232-232 (2017-11-23)
Though the human fetus is exposed to placentally derived human chorionic gonadotropin (hCG) throughout gestation, the role of hCG on the fetal brain is unknown. Review of the available literature appears to indicate that groups of women with higher mean
The superovulation of synchronous adult rats using follicle-stimulating hormone delivered by continuous infusion
Scott H G and Armstrong D T
Biology of Reproduction, 44(5), 851-856 (1991)

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