Non-Binding surface (NBS) multiwell plates have a modified polymer surface (PS) which results in a non-ionic hydrophilic surface (polyethylene oxide-like), thereby minimizing bio-interaction and enhancing the signal-to-noise ratio. Results have demonstrated NBS′s ability to significantly reduce protein and nucleic acid binding to polymers (<2 ng/cm2; over 90% reduction of protein binding compare to PS & PP surface), maintain enzyme activity, and inhibit adhesion of a number of cell lines. These novel surface technologies for assay plates are ideal for homogeneous assays such as Scintillation Proximity Assay (SPA). In addition to a 20+ fold increase in signal-to-noise ratio, selected assays have also displayed improved sensitivity and specificity. The recommended working volume of up to 75 μL to 200 μL for 96 well plates and 20μL to 80 μL for 384 well plates.
Corning is a registered trademark of Corning, Inc.
NBS is a trademark of Corning, Inc.