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D0390

Sigma-Aldrich

NG,NG′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt

≥99% (TLC)

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Synonym(s):
SDMA
Empirical Formula (Hill Notation):
C8H18N4O2 · 2C12H10N2O4S
CAS Number:
Molecular Weight:
758.82
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

assay

≥99% (TLC)

form

powder

solubility

methanol: 10 mg/mL

storage temp.

room temp

SMILES string

CN\C(NC)=N\CCC[C@H](N)C(O)=O.Oc1ccc(cc1)\N=N\c2ccc(cc2)S(O)(=O)=O.Oc3ccc(cc3)\N=N\c4ccc(cc4)S(O)(=O)=O

InChI

1S/2C12H10N2O4S.C8H18N4O2/c2*15-11-5-1-9(2-6-11)13-14-10-3-7-12(8-4-10)19(16,17)18;1-10-8(11-2)12-5-3-4-6(9)7(13)14/h2*1-8,15H,(H,16,17,18);6H,3-5,9H2,1-2H3,(H,13,14)(H2,10,11,12)/b2*14-13+;/t;;6-/m..0/s1

InChI key

HISUXCNNXYEHER-YJSASASGSA-N

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A8003

Allopurinol

vibrant-m

D4000

trans-Dehydroandrosterone

assay

≥99% (TLC)

assay

≥98% (TLC)

assay

≥99% (TLC)

assay

≥99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

crystalline powder

solubility

methanol: 10 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Application

Plasma sym-dimethylarginine has been considered a marker of hepatic and renal dysfunction. A sensitive LC-MS method for identifying arginine, and both asym- and sym-dimethylarginine in plasma and urine samples has been developed.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Jane Yu et al.
Animals : an open access journal from MDPI, 10(6) (2020-06-12)
The pharmacokinetic profile of mefloquine was investigated as a preliminary study towards a potential treatment for feline coronavirus infections (such as feline infectious peritonitis) or feline calicivirus infections. Mefloquine was administered at 62.5 mg orally to seven clinically healthy cats
Lena Pelander et al.
Journal of veterinary internal medicine, 33(2), 630-639 (2019-02-23)
Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required. To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection
Bob Siegerink et al.
Clinical research in cardiology : official journal of the German Cardiac Society, 102(3), 193-202 (2012-10-18)
Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor, which has been associated with total and cardiovascular mortality in various clinical settings. Studies on its structural isomer, symmetric dimethylarginine (SDMA), are scarce. This study aimed to determine the associations
Guozhen Gao et al.
Nucleic acids research, 45(8), 4359-4369 (2017-01-25)
The type II arginine methyltransferase PRMT5 is responsible for the symmetric dimethylation of histone to generate the H3R8me2s and H4R3me2s marks, which correlate with the repression of transcription. However, the protein level of a number of genes (MEP50, CCND1, MYC
D P Dahlem et al.
Journal of veterinary internal medicine, 31(3), 799-804 (2017-04-04)
Symmetric dimethylarginine (SDMA) is considered a biomarker for early detection of renal dysfunction in human patients with acute kidney injury (AKI). At present, no studies exist analyzing the relevance of SDMA in dogs with AKI. SDMA would correctly identify dogs

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