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D0633

Sigma-Aldrich

7-(2,3-Dihydroxypropyl)theophylline

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Synonym(s):
7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, Diprophylline, Dyphylline
Empirical Formula (Hill Notation):
C10H14N4O4
CAS Number:
Molecular Weight:
254.24
Beilstein/REAXYS Number:
284563
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

mp

161-162 °C (lit.)

SMILES string

CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

InChI key

KSCFJBIXMNOVSH-UHFFFAOYSA-N

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1 of 4

This Item
D28000001231502T1633
vibrant-m

D0633

7-(2,3-Dihydroxypropyl)theophylline

vibrant-m

D2800000

Diprophylline

vibrant-m

1231502

Dyphylline

vibrant-m

T1633

Theophylline

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

200

mp

161-162 °C (lit.)

mp

161-162 °C (lit.)

mp

161-162 °C (lit.)

mp

-

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Pde1b(29691), Pde3a(50678)

Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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S H Neau et al.
International journal of pharmaceutics, 179(1), 97-105 (1999-03-04)
Release data from ethylcellulose (EC) matrix tablets was analyzed to determine which release equation provides the best fit to the data and to observe the effect of drug solubility on the release mechanism(s). Tablets were prepared by direct compression of
Judyta Cielecka-Piontek et al.
Journal of pharmaceutical and biomedical analysis, 46(1), 52-57 (2007-10-16)
The following first-order rate constants of the degradation of ertapenem in INVANZ and meropenem in MERONEM were determined: (a) in dry air at 363, 373, 378, 383, 388, 393 K; (b) at increased relative air humidity (76.4% RH) at 313
Joshua Müller et al.
Drug development and industrial pharmacy, 36(2), 234-243 (2009-09-26)
Active coating is a specific application of film coating where the active ingredient is comprised in the coating layer. This implementation is a challenging operation regarding the achievement of desired amount of coating and coating uniformity. To guarantee the quality
Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography (2017)
Mario Grassi et al.
International journal of pharmaceutics, 276(1-2), 107-114 (2004-04-29)
A mathematical model able to describe the release kinetics of two model drugs (Diprophylline and Theophylline) from partially coated hydroxypropylmethylcellulose (HPMC, Methocel) K4M) matrices is presented. As solvent interaction with the system and drug release can only take place in

Articles

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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