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D1756

Sigma-Aldrich

Dexamethasone

≥98% (HPLC), powder

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Synonym(s):
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
Molecular Weight:
392.46
Beilstein:
2066651
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

off-white

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

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1 of 4

This Item
31375D8893D4902
Dexamethasone ≥98% (HPLC), powder

Sigma-Aldrich

D1756

Dexamethasone

Dexamethasone tested according to Ph. Eur.

Sigma-Aldrich

31375

Dexamethasone

Dexamethasone powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Sigma-Aldrich

D8893

Dexamethasone

Dexamethasone powder, BioReagent, suitable for cell culture, ≥97%

Sigma-Aldrich

D4902

Dexamethasone

form

powder

form

solid

form

powder

form

powder

color

off-white

color

-

color

-

color

-

solubility

methanol: 25 mg/mL

solubility

water: soluble 10mg/100 ml at 25 °C, acetone: very slightly soluble, alcohol: very slightly soluble, chloroform: slightly soluble, diethyl ether: very slightly soluble, dioxane: very slightly soluble, methanol: very slightly soluble

solubility

ethanol: 1 mL/vial, clear

solubility

methanol: 25 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

-

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

Application

Dexamethasone has been used:
  • in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue
  • as a component of adipocyte differentiation medium
  • for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)

Biochem/physiol Actions

Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Reconstitution

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

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Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

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  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

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Dexamethasone European Pharmacopoeia (EP) Reference Standard

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Dexamethasone

Rosiglitazone ≥98% (HPLC)

Sigma-Aldrich

R2408

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Indomethacin 98.5-100.5% (in accordance with EP)

Sigma-Aldrich

I7378

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Dexamethasone United States Pharmacopeia (USP) Reference Standard

USP

1176007

Dexamethasone

Increased expression of ADAM33 and ADAM8 with disease progression in asthma
Foley SC, et al.
The Journal of Allergy and Clinical Immunology, 119(4), 863-871 (2007)
Dexamethasone in adults with bacterial meningitis
De Gans J and Van de BD
The New England Journal of Medicine, 347(20), 1549-1556 (2002)
Magdalena Pasarica et al.
Stem cells (Dayton, Ohio), 26(4), 969-978 (2008-01-22)
Human adenovirus Ad-36 is causatively and correlatively linked with animal and human obesity, respectively. Ad-36 enhances differentiation of rodent preadipocytes, but its effect on adipogenesis in humans is unknown. To indirectly assess the role of Ad-36-induced adipogenesis in human obesity
Canine adipose-derived-mesenchymal stem cells do not lose stem features after a long-term cryopreservation
Martinello T, et al.
Research in Veterinary Science, 91(1), 18-24 (2011)
Yanan Wu et al.
Polymers, 11(5) (2019-05-11)
Many studies about fabricating organic-inorganic composite materials have been carried out in order to mimic the natural structure of bone. Pearl, which has a special block-and-mortar hierarchical structure, is a superior bone repair material with high osteogenic activity, but it

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