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D3768

Sigma-Aldrich

Dequalinium chloride hydrate

≥95% (titration)

Synonym(s):
1,1′-Decamethylenebis(4-aminoquinaldinium) dichloride hydrate
Empirical Formula (Hill Notation):
C30H40Cl2N4 · xH2O
CAS Number:
Molecular Weight:
527.57 (anhydrous basis)
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

assay

≥95% (titration)

form

powder

mp

≥300 °C (lit.)

SMILES string

O.[Cl-].[Cl-].Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34

InChI

1S/C30H38N4.2ClH.H2O/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34;;;/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3;2*1H;1H2

InChI key

CZCJAGQJOXJBST-UHFFFAOYSA-N

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Packaging

5 g in poly bottle

Biochem/physiol Actions

Dequalinium chloride is a selective blocker of apamin-sensitive K+ channels and inhibitor of XIAP (X-linked inhibitor of apoptosis protein). Has been shown to induce cytotoxicity in human acute promyelocytic leukemia NB4 cells through disturbance of mitochondrial function, oxidative stress, and downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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