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D4266

Sigma-Aldrich

3-(Decyldimethylammonio)­propane­sulfonate inner salt

zwitterionic detergent

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Synonym(s):
Caprylyl sulfobetaine, SB3-10
Linear Formula:
CH3(CH2)9N+(CH3)2CH2CH2CH2SO3-
CAS Number:
Molecular Weight:
307.49
Beilstein:
3967284
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Assay

≥98.0% (TLC)

form

powder

mol wt

micellar avg mol wt 12,600

aggregation number

41

technique(s)

enzyme immunoassay: suitable
protein purification: suitable
protein quantification: suitable

conductivity

<20 μmho per cm at 24 °C (0.1 M aqueous solution)

CMC

25-40 mM (20-25°C)

SMILES string

CCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O

InChI

1S/C15H33NO3S/c1-4-5-6-7-8-9-10-11-13-16(2,3)14-12-15-20(17,18)19/h4-15H2,1-3H3

Inchi Key

WKALLSVICJPZTM-UHFFFAOYSA-N

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1 of 4

This Item
D043140772H6883
form

powder

form

powder

form

-

form

-

mol wt

micellar avg mol wt 12,600

mol wt

micellar avg mol wt 18,500

mol wt

micellar avg mol wt 30,200

mol wt

micellar avg mol wt 60,700

aggregation number

41

aggregation number

55

aggregation number

83

aggregation number

155

technique(s)

enzyme immunoassay: suitable, protein purification: suitable, protein quantification: suitable

technique(s)

-

technique(s)

nucleic acid detection: suitable, protein purification: suitable, protein quantification: suitable

technique(s)

electrophoresis: suitable, mass spectrometry (MS): suitable, thin layer chromatography (TLC): suitable

CMC

25-40 mM (20-25°C)

CMC

2-4 mM (20-25°C)

CMC

0.1-0.4 mM (20-25°C)

CMC

0.01-0.06 mM (20-25°C)

General description

3-(Decyldimethylammonio)­propane­sulfonate inner salt, a zwitterionic surfactant, is a sulfobetaine. Sulfobetaines contain a positively charged quaternary ammonium group and a negatively charged sulfonic group.

Application

3-(Decyldimethylammonio)­propane­sulfonate inner salt was used:
  • In a study to demonstrate a polyurethane chip that electrostatically binds to immunoglobulin G (IgG).
  • In a study to describe a method for isolating a high yield of Arabidopsis chloroplasts.
  • Solubilization of oleosins.
Zwitterionic detergent used for protein solubilization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Kenji Murakami et al.
The Journal of biological chemistry, 288(9), 6325-6332 (2013-01-11)
Whereas individual RNA polymerase II (pol II)-general transcription factor (GTF) complexes are unstable, an assembly of pol II with six GTFs and promoter DNA could be isolated in abundant homogeneous form. The resulting complete pol II transcription preinitiation complex (PIC)
Sybille E Kubis et al.
Methods in molecular biology (Clifton, N.J.), 425, 171-186 (2008-03-29)
A major area of research in the postgenomic era has been the proteomic analysis of various subcellular and suborganellar compartments. The success of these studies is to a large extent dependent upon efficient protocols for the preparation of highly pure
W Schulz et al.
Journal of steroid biochemistry, 32(4), 581-590 (1989-04-01)
11 beta-hydroxysteroid dehydrogenase (11-HSD, EC 1.1.1.146) from rat renal cortex microsomes was solubilized using several detergents, the most effective being Zwittergent 3-10 and Triton X-100. The activity ratio oxidation/reduction of the reversible reaction corticosterone in equilibrium 11-dehydrocoticosterone varied depending on
Katarzyna Derwinska et al.
Analytica chimica acta, 592(2), 132-138 (2007-05-22)
Hydrogels are considered an optimum material for protein chip surfaces, since they provide a quasi-liquid environment which allows protein activity to be maintained and shows good spot morphology as well as excellent immobilization capacity. In the following, we present a
Kenji Murakami et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(13), 4816-4821 (2012-03-14)
General transcription factor TFIIH, previously described as a 10-subunit complex, is essential for transcription and DNA repair. An eleventh subunit now identified, termed Tfb6, exhibits 45% sequence similarity to human nuclear mRNA export factor 5. Tfb6 dissociates from TFIIH as

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