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D4788

Sigma-Aldrich

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

100 mM, pH 7

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Synonym(s):
dATP
EC Number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.52

Assay

≥99%

form

liquid

concentration

100 mM

color

colorless

pH

7

foreign activity

DNase, RNase, none detected

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)O3

InChI

1S/C10H16N5O12P3.Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);/q;+1/p-1/t5-,6+,7+;/m0./s1

InChI key

YJWCICGGRLOGEH-VWZUFWLJSA-M

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1 of 4

This Item
D692011051440001DATP-RO
dATP =98%, solution, 100 mM, suitable for DNA sequencing, suitable for DNA amplification

Roche

11051440001

dATP

dATP 99% (dNTP), <0.9% (dNDP), solution, 100 mM

Roche

DATP-RO

dATP

form

liquid

form

liquid

form

solution

form

solution

concentration

100 mM

concentration

10 mM

concentration

100 mM

concentration

<0.9% (dNDP), 100 mM

color

colorless

color

colorless

color

-

color

-

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

2′-Deoxyadenosine 5′-triphosphate (dATP) is made up of a nucleobase attached to deoxyribose and a 5′-hydroxyl on the sugar bound to a chain of three phosphate residues. dATP is used by cells for synthesis of DNA by DNA polymerases.

Application

2′-Deoxyadenosine 5′-triphosphate sodium salt solution has been used in the detection of apoptotic cells by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique. It has also been used to induce oligomerization of apoptotic protease activating factor-1 (Apaf-1) to form a large heptameric complex referred to as the apoptosome or Apaf-1 procaspase-9 apoptosome complex and to study its functions as a proteolytic-based molecular timer.
2′-Deoxyadenosine 5′-triphosphate sodium salt solution is used in DNA sysnthesis reactions such as PCR, DNA sequencing and molecular cloning techniques.

Components

T4 DNA Ligaes is supplied in a solution containing 20 mM Tris-HCl(ph 7.5), 50mM KCl, 1mM DTT, and 50% (v/v) glycerol

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Ultrasound-guided intramural inoculation of orthotopic bladder cancer xenografts: a novel high-precision approach
Jager W, et al.
Testing, 8(3), e59536-e59536 (2013)
Kevin N Kirouac et al.
Nucleic acids research, 41(3), 2060-2071 (2012-12-27)
Nitrated polycyclic aromatic hydrocarbons are common environmental pollutants, of which many are mutagenic and carcinogenic. 1-Nitropyrene is the most abundant nitrated polycyclic aromatic hydrocarbon, which causes DNA damage and is carcinogenic in experimental animals. Error-prone translesion synthesis of 1-nitropyrene-derived DNA
Heqiao Dai et al.
Gynecologic oncology, 131(1), 198-206 (2013-07-16)
The objective of this study is to determine whether an altered DNA replication process is responsible for some of genetic damage observed in ovarian cancer. The replication fidelity of the DNA synthetic process was evaluated in both malignant and non-malignant
Anders Hofer et al.
Critical reviews in biochemistry and molecular biology, 47(1), 50-63 (2011-11-05)
Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when
Paul J Rothwell et al.
The Journal of biological chemistry, 288(19), 13575-13591 (2013-03-26)
Conformational selection plays a key role in the polymerase cycle. Klentaq1 exists in conformational equilibrium between three states (open, closed, and “nucleotide-binding”) whose level of occupancy is determined by the bound substrate. The “nucleotide-binding” state plays a pivotal role in

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