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MilliporeSigma

D4788

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

≥99%, liquid

Synonym(s):

dATP

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25 μMOL

$127.00

0.1 MMOL

$385.00

$127.00

Estimated to ship onMay 06, 2026Details

About This Item

UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24893898
NACRES:
NA.52
EC Number:
217-662-3
Assay:
≥99%
Form:
liquid
Storage temp.:
−20°C

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Product Name

2′-Deoxyadenosine 5′-triphosphate sodium salt solution, 100 mM, pH 7

assay

≥99%

form

liquid

InChI

1S/C10H16N5O12P3.Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);/q;+1/p-1/t5-,6+,7+;/m0./s1

InChI key

YJWCICGGRLOGEH-VWZUFWLJSA-M

SMILES string

[Na+].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)O3

concentration

100 mM

color

colorless

pH

7

foreign activity

DNase, RNase, none detected

shipped in

dry ice

storage temp.

−20°C

Quality Level

300

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1 of 4

This Item
D692011051440001DATP-RO
2′-Deoxyadenosine 5′-triphosphate sodium salt solution 100 mM, pH 7

Sigma-Aldrich

D4788

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

2′-Deoxyadenosine 5′-triphosphate sodium salt solution 10 mM

Sigma-Aldrich

D6920

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

dATP =98%, solution, 100 mM, suitable for DNA sequencing, suitable for DNA amplification

Roche

11051440001

dATP

dATP 99% (dNTP), <0.9% (dNDP), solution, 100 mM

Roche

DATP-RO

dATP

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

100

form

liquid

form

liquid

form

solution

form

solution

assay

≥99%

assay

≥99%

assay

98%

assay

99% (dNTP)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

concentration

100 mM

concentration

10 mM

concentration

100 mM

concentration

<0.9% (dNDP), 100 mM

color

colorless

color

colorless

color

-

color

-

General description

2′-Deoxyadenosine 5′-triphosphate (dATP) is made up of a nucleobase attached to deoxyribose and a 5′-hydroxyl on the sugar bound to a chain of three phosphate residues. dATP is used by cells for synthesis of DNA by DNA polymerases.

Application

2′-Deoxyadenosine 5′-triphosphate sodium salt solution has been used in the detection of apoptotic cells by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique.[1] It has also been used to induce oligomerization of apoptotic protease activating factor-1 (Apaf-1) to form a large heptameric complex referred to as the apoptosome or Apaf-1 procaspase-9 apoptosome complex and to study its functions as a proteolytic-based molecular timer.[2]
2′-Deoxyadenosine 5′-triphosphate sodium salt solution is used in DNA sysnthesis reactions such as PCR, DNA sequencing and molecular cloning techniques.

Other Notes

T4 DNA Ligaes is supplied in a solution containing 20 mM Tris-HCl(ph 7.5), 50mM KCl, 1mM DTT, and 50% (v/v) glycerol

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF0584V
0000284880
0000381284
0000381284
0000383546

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Ultrasound-guided intramural inoculation of orthotopic bladder cancer xenografts: a novel high-precision approach
Jager W, et al.
Testing, 8(3), e59536-e59536 (2013)
Srinivas Malladi et al.
The EMBO journal, 28(13), 1916-1925 (2009-06-06)
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed caspase-9 is paradoxically observed outside the complex. We show herein
U C Halder et al.
Cell death & disease, 2, e197-e197 (2011-09-02)
During early infection, viruses activate cellular stress-response proteins such as heat-shock proteins (Hsps) to counteract apoptosis, but later on, they modulate these proteins to stimulate apoptosis for efficient viral dissemination. Hsp70 has been attributed to modulate viral entry, transcription, nuclear
Christina M Zimanyi et al.
Structure (London, England : 1993), 20(8), 1374-1383 (2012-06-26)
Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits
Serdal Kirmizialtin et al.
Structure (London, England : 1993), 20(4), 618-627 (2012-04-10)
Nearly every enzyme undergoes a significant change in structure after binding it's substrate. Experimental and theoretical analyses of the role of changes in HIV reverse transcriptase structure in selecting a correct substrate are presented. Atomically detailed simulations using the Milestoning
View All Related Papers

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