≥96% (TLC), oil

(S)-Glycerol 1,2-dioctanoate, D-α,β-Dicaprylin, 1,2-Dicapryloyl-sn-glycerol, DOG
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
PubChem Substance ID:


≥96% (TLC)






DMSO: soluble

shipped in

dry ice

storage temp.


SMILES string


Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.

Other Notes

Synthetic 1,2-diglyceride of short chain fatty acid.


Some isomerization to the 1,3-isomer may occur in storage or in solution.

Certificate of Analysis

Certificate of Origin

Weera Piyatheerawong et al.
Journal of chromatography. A, 1068(2), 243-248 (2005-04-16)
A novel HPLC-based method for direct separation of the three isomers of mono-acid diacylglycerols (DAGs), i.e., 1,2-DAG, 2,3-DAG and 1,3-DAG, has been established. The method employs a tandem column system, in which two different columns (a conventional silica gel column...
Johnny Näsman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(42), 10658-10666 (2006-10-20)
We studied the cellular response to orexin type 1 receptor (OX1R) stimulation in differentiated IMR-32 neuroblastoma cells. In vitro differentiation of IMR-32 cells with 5-bromo-2'-deoxyuridine leads to a neuronal phenotype with long neurite extensions and an upregulation of mainly N-type...
S E Gordon et al.
Biophysical journal, 69(2), 409-417 (1995-08-01)
The electrical response to light in retinal rods is mediated by cyclic nucleotide-gated, nonselective cation channels in the outer segment plasma membrane. Although cGMP appears to be the primary light-regulated second messenger, cellular levels of other substances, including Ca2+ and...
Carole A Farah et al.
Molecular and cellular biology, 28(15), 4719-4733 (2008-05-29)
In Aplysia californica, the serotonin-mediated translocation of protein kinase C (PKC) Apl II to neuronal membranes is important for synaptic plasticity. The orthologue of PKC Apl II, PKCepsilon, has been reported to require phosphatidic acid (PA) in conjunction with diacylglycerol...
Shandra A Doran et al.
Canadian journal of physiology and pharmacology, 84(6), 635-646 (2006-08-11)
We examined the roles of Ca2+ and protein kinase C (PKC) in the cilio-excitatory response to serotonin in pedal ciliary cells from Helisoma trivolvis embryos. Serotonin (5-hydroxytryptamine; 5-HT; 100 micromol/L) induced an increase in ciliary beat frequency (CBF) was abolished...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service