D6196

Dimebon dihydrochloride hydrate

≥98% (HPLC)

• Synonym(s): 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate
• Empirical Formula (Hill Notation): C₂₁H₂₅N₃ · 2HCl · xH₂O
• CAS Number: 97657-92-6
• Molecular Weight: 392.37 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329798824
• UNSPSC Code: 12352200
• MDL number: MFCD17215933
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Properties

• InChI key: QQHQMWVYYVVAOV-UHFFFAOYSA-N
• SMILES string: O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
• InChI: 1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: ≥10 mg/mL
• storage temp.: 2-8°C
• Quality Level: 100

Description

Biochem/physiol Actions

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable