D6382

N,N-Dimethylglycine hydrochloride

Name: <I>N,N</I>-Dimethylglycine hydrochloride
Brand: SIGMA

≥98%, suitable for ligand binding assays

Synonym(s):

N,N-Dimethylaminoacetic acid hydrochloride

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About This Item

Linear Formula:

(CH₃)₂NCH₂COOH · HCl

CAS Number:

2491-06-7

Molecular Weight:

139.58

Beilstein/REAXYS Number:

3910578

EC Number:

219-648-2

MDL number:

MFCD00012610

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24894022

NACRES:

NA.26

Key Documents

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Product Name

N,N-Dimethylglycine hydrochloride,

assay

≥98%

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white

mp

189-194 °C (lit.)

SMILES string

Cl.CN(C)CC(O)=O

InChI

1S/C4H9NO2.ClH/c1-5(2)3-4(6)7;/h3H2,1-2H3,(H,6,7);1H

InChI key

FKASAVXZZLJTNX-UHFFFAOYSA-N

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Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

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Show Differences

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This Item	D1156	L5751	C3647
Sigma-Aldrich D6382 N,N-Dimethylglycine hydrochloride	Sigma-Aldrich D1156 N,N-Dimethylglycine	Sigma-Aldrich L5751 L-Lysine dihydrochloride	Sigma-Aldrich C3647 Z-L-Lys-SBzl hydrochloride
form powder	form powder	form powder	form powder
technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable
assay ≥98%	assay ≥99%	assay ≥98% (HPLC)	assay ≥98% (TLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
color white	color white to off-white	color white to faint yellow	color white
mp 189-194 °C (lit.)	mp 178-182 °C (lit.)	mp 200-206 °C (lit.)	mp -

Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions.

Shuichi Setoguchi et al.

Molecules (Basel, Switzerland), 25(3) (2020-02-06)

The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel N,N-dimethylglycine

Characterization of osmolyte βine synthesizing sarcosine dimethylglycineN-methyltransferase from Methanohalophilus portucalensis.

Chen SY, Lai MC, Lai SJ, Lee YC.

Applied Microbiology, 191, 735-743 (2009)

Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions.

A J Hoorn

Mutation research, 222(4), 343-350 (1989-04-01)

Dimethylglycine (DMG) and the chemically related amino acids glycine, sarcosine (monomethylglycine) and betaine (trimethylglycine) were tested in Salmonella typhimurium strain TA100 after treatment with sodium nitrite under acidic conditions using a modified Ames Salmonella/microsome assay as reported by Colman et

Experimental and theoretical enthalpies of formation of glycine-based sulfate/bisulfate amino acid ionic liquids.

Jing-Fang Zhu et al.

The journal of physical chemistry. B, 116(1), 113-119 (2011-12-14)

The experimental and theoretical enthalpies of formation of several structural-similar glycine-based sulfate/bisulfate amino acid ionic liquids including glycine sulfate (Gly(2)SO(4), 1), glycine bisulfate (GlyHSO(4), 2), N,N-dimethylglycine sulfate ([DMGly](2)SO(4), 3), N,N-dimethylglycine bisulfate ([DMGly]HSO(4), 4), N,N-dimethylglycine methyl ester sulfate ([DMGlyC(1)](2)SO(4), 5), N,N-dimethylglycine

Metabolic profiling detects biomarkers of protein degradation in COPD patients.

Baljit K Ubhi et al.

The European respiratory journal, 40(2), 345-355 (2011-12-21)

There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers

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