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  • D6899
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D6899

Sigma-Aldrich

Diclofenac sodium salt

Synonym(s):
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Empirical Formula (Hill Notation):
C14H10Cl2NNaO2
CAS Number:
Molecular Weight:
318.13
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

Assay

≥98% (TLC)

form

powder

mp

283-285  °C

solubility

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

originator

Novartis

storage temp.

room temp

SMILES string

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KPHWPUGNDIVLNH-UHFFFAOYSA-M

Gene Information

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This Item
S076500039769PHR1144
Diclofenac sodium salt

Sigma-Aldrich

D6899

Diclofenac sodium salt

Diclofenac sodium European Pharmacopoeia (EP) Reference Standard

S0765000

Diclofenac sodium

Diclofenac sodium salt certified reference material, TraceCERT®

Supelco

39769

Diclofenac sodium salt

Diclofenac sodium salt Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1144

Diclofenac sodium salt

assay

≥98% (TLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

solubility

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

solubility

-

solubility

-

solubility

-

originator

Novartis

originator

-

originator

-

originator

-

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

2-30°C

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

300

Application

Diclofenac sodium has been used:
  • to investigate its radioprotective potential in a study
  • to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study
  • as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
  • to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs

Biochem/physiol Actions

Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.
Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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