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D7017

Sigma-Aldrich

Dynorphin A Porcine Fragment 1-13

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C75H126N24O15
CAS Number:
72957-38-1
Molecular Weight:
1603.95
MDL number:
MFCD00076366
UNSPSC Code:
12352202
PubChem Substance ID:
24894071
NACRES:
NA.32

Key Documents

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Quality Level

200

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥50%

UniProt accession no.

P01214

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)NC(CCCNC(N)=N)C(=O)N3CCCC3C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(O)=O

InChI

1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)

InChI key

OVVIBUHLQIYUEU-UHFFFAOYSA-N

Gene Information

pig ... PDYN(445529)

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Show Differences

1 of 4

This Item
D8147M4505G8147
Dynorphin A Porcine Fragment 1-13 ≥97% (HPLC)

Sigma-Aldrich

D7017

Dynorphin A Porcine Fragment 1-13

Dynorphin A porcine ≥95% (HPLC)

Sigma-Aldrich

D8147

Dynorphin A porcine

Motilin porcine ≥97% (HPLC)

Sigma-Aldrich

M4505

Motilin porcine

Glucagon-Like Peptide I Amide Fragment 7-36 human ≥97% (HPLC), powder

Sigma-Aldrich

G8147

Glucagon-Like Peptide I Amide Fragment 7-36 human

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

-

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

pig ... PDYN(445529)

Gene Information

human ... OPRK1(4986)
mouse ... Oprd1(18386)
pig ... PDYN(445529)
rat ... Oprd1(24613)

Gene Information

pig ... MLN(397466)

Gene Information

human ... GCG(2641)

UniProt accession no.

P01214

UniProt accession no.

P01214, P32300, P33533, P41145

UniProt accession no.

P01307

UniProt accession no.

P01275

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys

Application

Dynorphin A Porcine Fragment 1-13 has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).[1]

Biochem/physiol Actions

Dynorphin (Dyn) (1-13), a bioactive product of dynorphin A[2] displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors.[3] It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN5933
SLCJ5025
SLBV4020
SLBN9253V
SLBK8305V

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Mark S Wallace et al.
Journal of opioid management, 2(3), 167-173 (2007-02-27)
CJC-1008 is a chemical modification of the opioid peptide dynorphin A (1-13) (Dyn A) that promotes dynorphin's covalent attachment to human serum albumin in vivo after administration, thus prolonging its duration of action. The primary objective of this study was
Jing Liang et al.
Neuropharmacology, 58(1), 233-240 (2009-07-15)
Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing
M Hiramatsu et al.
Methods and findings in experimental and clinical pharmacology, 20(7), 595-599 (1998-11-20)
The role of kappa-opioid receptor agonists on learning and memory is controversial. In this review, the effects of dynorphin A (1-13) and U-50,488H on learning and memory impairments in mice and rats are summarized. Muscarinic cholinergic antagonists and a nicotinic
B Brugos et al.
Die Pharmazie, 59(5), 339-343 (2004-06-24)
Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of
Sylvie Tordjman et al.
Behavior genetics, 33(5), 529-536 (2003-10-24)
Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred
View All Related Papers

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