D7910

3,4-Dichloroisocoumarin

serine protease inhibitor

• Synonym(s): 3,4-Dichloro-2-benzopyran-1-one, 3,4-DCI
• Empirical Formula (Hill Notation): C₉H₄Cl₂O₂
• CAS Number: 51050-59-0
• Molecular Weight: 215.03
• Beilstein/REAXYS Number: 6802625
• MDL number: MFCD00036960
• PubChem Substance ID: 24278386
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: ClC1=C(Cl)c2ccccc2C(=O)O1
• InChI: 1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
• InChI key: SUGXUUGGLDCZKB-UHFFFAOYSA-N

Description

Packaging

5, 10, 25 mg in glass bottle

Application

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC^®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Effective concentration 5-100 μM.

Quantity

Half-life = 20 min at pH 7.5.

Substrates

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 - H315 - H319 - H335
• Precautionary Statements: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Target Organs: Respiratory system
• Personal Protective Equipment: dust mask type N95 (US),Eyeshields,Gloves
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable