D7910

3,4-Dichloroisocoumarin

serine protease inhibitor

• Synonym(s): 3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one
• Empirical Formula (Hill Notation): C₉H₄Cl₂O₂
• CAS Number: 51050-59-0
• Molecular Weight: 215.03
• Beilstein/REAXYS Number: 6802625
• MDL number: MFCD00036960
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278386
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: ClC1=C(Cl)c2ccccc2C(=O)O1
• InChI: 1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
• InChI key: SUGXUUGGLDCZKB-UHFFFAOYSA-N

Description

Application

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.[1]

Other Notes

Effective concentration 5-100 μM.

Quantity

Half-life = 20 min at pH 7.5.

Substrates

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges