D8040

(±)-trans-U-50488 methanesulfonate salt

• Synonym(s): trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate salt, U-50488H
• Empirical Formula (Hill Notation): C₁₉H₂₆Cl₂N₂O · CH₄O₃S
• Molecular Weight: 465.43
• MDL number: MFCD00133867
• PubChem Substance ID: 24278070

Properties

• form: powder
• Quality Level: 200
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
• InChI: 1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1
• InChI key: OJPHNZCUXUUVKU-JAXOOIEVSA-N
• Gene Information: human ... OPRK1(4986)

Description

Application

(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.

Packaging

10 mg in poly bottle

50, 100 mg in glass bottle

Biochem/physiol Actions

Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves