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D8783

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt

10 mM in H2O

Synonym(s):

−N7-dGTP, 7-Deaza-dGTP

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0.5 μMOL

$153.00

$153.00

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About This Item

Empirical Formula (Hill Notation):
C11H17N4O13P3
CAS Number:
101515-08-6
Molecular Weight:
506.19
NACRES:
NA.52
PubChem Substance ID:
24894227
UNSPSC Code:
41106305
MDL number:
MFCD00171614

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Product Name

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt, 10 mM in H2O

InChI

1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)

SMILES string

NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1

InChI key

DLLXAZJTLIUPAI-UHFFFAOYSA-N

biological source

Porcine muscle
rabbit muscle

assay

≥95% (HPLC)

form

liquid

concentration

10 mM in H2O

color

colorless

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

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1 of 4

This Item
G3776D4010D7170
7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt 10 mM in H2O

Sigma-Aldrich

D8783

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt

Guanosine 5′-triphosphate sodium salt solution HPLC purified, aqueous solution for RNA polymerase transcription

Sigma-Aldrich

G3776

Guanosine 5′-triphosphate sodium salt solution

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate ≥96% (HPLC)

Sigma-Aldrich

D4010

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate

2′-Deoxyguanosine 5′-triphosphate trisodium salt solution 10 mM in H2O

Sigma-Aldrich

D7170

2′-Deoxyguanosine 5′-triphosphate trisodium salt solution

biological source

Porcine muscle, rabbit muscle

biological source

Porcine brain, bacterial (Corynebacterium), yeast

biological source

synthetic (organic)

biological source

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

liquid

form

liquid

form

powder

form

liquid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥96% (HPLC)

assay

≥99%

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

color

colorless

color

colorless

color

-

color

colorless

Application

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt has been used as a lysis agent to evaluate its efficiency on direct cell lysis, RNA stability, and compatibility with downstream reverse transcription quantitative real-time PCR during the analyzes of samples with small numbers of cells.[1]

Biochem/physiol Actions

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-deaza-dGTP) competes with natural substrate dGTP and blocks the telomerase activity. This nucleotide once incorporated into the telomere alters the secondary structure of the telomere making it difficult for telomerase to identify it for further telomere synthesis.[2] This dGTP analog pairs weakly with conventional bases to minimize DNA secondary structures, while being a good substrate for DNA polymerases. 7-deaza-dGTP in combination with dimethyl sulfoxide (DMSO) and betaine enhances the polymerase chain reaction (PCR) amplification of GC-rich DNA sequences.[3]

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000450253
0000450253
0000364518
0000317837
0000310845

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Nucleic acids research, 40(20), 10334-10344 (2012-09-12)
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