D9069

Sigma-Aldrich

N-Desmethyltamoxifen HCl

≥98% (HPLC), solid

Synonym(s):
(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, ICI 55,548
Empirical Formula (Hill Notation):
C25H27NO·HCl
CAS Number:
Molecular Weight:
393.95
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

sterility

non-sterile

assay

≥98% (HPLC)

form

solid

application(s)

inhibition assay: suitable

solubility

DMSO: ≥20 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

Cl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3

InChI

1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

InChI key

GMLHJWZEYLTNJW-BJFQDICYSA-N

Application

N-Desmethyltamoxifen HCl has been used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Health hazardEnvironment

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes
Hackett AR, et al.
Experimental Neurobiology, 308, 72-79 (2018)
Articles
Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.
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We offers many products related to Nuclear Receptors (Steroids) for your research needs.
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