E0276

Sigma-Aldrich

EPPS

BioPerformance Certified, suitable for cell culture, ≥99.5% (titration)

Synonym(s):
N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), HEPPS, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid
Empirical Formula (Hill Notation):
C9H20N2O4S
CAS Number:
Molecular Weight:
252.33
Beilstein/REAXYS Number:
3957385
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

grade

BioPerformance Certified

Quality Level

assay

≥99.5% (titration)

application(s)

cell culture | mammalian: suitable

impurities

endotoxin and Total Aerobic Microbial Count, tested

pH range

7.3 - 8.7

useful pH range

7.3 - 8.7

pKa (25 °C)

8.0

pKa 

8

mp

237-239 °C (lit.)

solubility

H2O: 25 g + 50 mL, clear, colorless

cation traces

heavy metals (as Pb): ≤5 ppm

λmax

A290 at ≤0.1 (C=33% w/w)

Featured Industry

Diagnostic Assay Manufacturing

SMILES string

OCCN1CCN(CCCS(O)(=O)=O)CC1

InChI

1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

InChI key

OWXMKDGYPWMGEB-UHFFFAOYSA-N

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RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Xiannu Jin et al.
Journal of pharmacological and toxicological methods, 70(2), 188-194 (2014-08-26)
Malaria is a major health concern and affects over 300million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-malarial drugs is to design active molecules that have preferable...
Feng Xie et al.
Cancer letters, 364(2), 106-117 (2015-05-17)
Cervical cancer is often associated with eosinophil (EOS) infiltration, but the source and the role of EOS are still largely unknown. Our previous work has established that thymic stromal lymphopoietin (TSLP) can stimulate the growth of cervical cancer cell in...
Calvin R Justus et al.
Experimental cell research, 334(1), 100-113 (2015-04-08)
The effect of acidosis, a biochemical hallmark of the tumor microenvironment, on cancer progression and metastasis is complex. Both pro- and anti-tumorigenic effects of acidosis have been reported and the acidic microenvironment has been exploited for specific delivery of drugs...
Anindya Sarkar et al.
The Journal of biological chemistry, 290(35), 21615-21628 (2015-07-03)
Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide (NO)-responsive active form. We utilized fluorescence...

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