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EPPS

Name: EPPS
Brand: SIGMA
Price: 171 USD
Availability: InStock

BioPerformance Certified, suitable for cell culture, ≥99.5% (titration)

Synonym(s):

4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), HEPPS

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Pack Size	SKU	Availability	Price
100 g		Estimated to ship onMay 07, 2026fromMILWAUKEE	$171.00
500 g		Estimated to ship onMay 07, 2026fromMILWAUKEE	$587.00

About This Item

Empirical Formula (Hill Notation):

C₉H₂₀N₂O₄S

CAS Number:

16052-06-5

Molecular Weight:

252.33

UNSPSC Code:

12161700

NACRES:

NA.25

PubChem Substance ID:

24894366

EC Number:

240-198-8

Beilstein/REAXYS Number:

3957385

MDL number:

MFCD00006160

$171.00

Estimated to ship onMay 07, 2026Details

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Properties

grade

BioPerformance Certified

Quality Level

400

assay

≥99.5% (titration)

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin and Total Aerobic Microbial Count, tested

pH

7.3-8.7

useful pH range

7.3-8.7

pKa (25 °C)

8.0

pKa

mp

237-239 °C (lit.)

solubility

H₂O: 25 g + 50 mL, clear, colorless

cation traces

heavy metals (as Pb): ≤5 ppm

λ_max

A290 at ≤0.1 (C=33% w/w)

application(s)

diagnostic assay manufacturing

SMILES string

OCCN1CCN(CCCS(O)(=O)=O)CC1

InChI

1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

InChI key

OWXMKDGYPWMGEB-UHFFFAOYSA-N

Description

General description

EPPS or 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (HEPPS) is a zwitterionic buffer substance from the group of good buffers. It effectively maintains constant pH in a solution, which is necessary for many biological and biochemical reactions. EPPS buffer is widely used in cell culture experiments and biological research.

Application

EPPS may be used as a buffer solution to stabilize the pH in sea water samples during the titration experiments.

Features and Benefits

BioPerformance Certified, high-quality level (400), ensures reliable and consistent results.
Suitable for mammalian cell culture techniques

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Show Differences

1 of 1

This Item	E9502	E1894	H3784
Sigma-Aldrich E0276 EPPS	Sigma-Aldrich E9502 EPPS	Sigma-Aldrich E1894 EPPS	Sigma-Aldrich H3784 HEPES sodium salt
application(s) diagnostic assay manufacturing	application(s) diagnostic assay manufacturing	application(s) diagnostic assay manufacturing	application(s) cell analysis diagnostic assay manufacturing general analytical life science and biopharma
form crystalline powder	form powder	form powder	form powder
technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) -	technique(s) activity assay: suitable, cell culture \| mammalian: suitable
grade BioPerformance Certified	grade -	grade -	grade BioPerformance Certified
solubility H₂O: 25 g + 50 mL, clear, colorless	solubility H₂O: 25 g + 50 mL, clear, colorless	solubility H₂O: 1 M at 20 °C, clear, colorless	solubility water: 0.1 M, clear, colorless
Quality Level 400	Quality Level 400	Quality Level 400	Quality Level 400

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000525700

0000430311

0000414531

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lonization Enthalpies of Some Common Zvvitterionic Hydrogen-lon Buffers (HEPES, PIPES, HEPPS and BES) for Biological Research

Roig T, et al.

Journal of Separation Science, 993(47), 899-90j-899-90j (1993)

Equilibrium studies, synthesis, and characterization of zwitterionic buffer (HEPES and HEPPS) dimethyltin (IV) complexes

Mahmoud M, et al.

Main Group Chemistry, 6(2) (2007)

The characteristics of Fe speciation and Fe-binding ligands in the Mariana back-arc hydrothermal plumes

Wang H R, et al.

Geochimica et Cosmochimica Acta, 292, 24-36 (2021)

View All Related Papers

Global Trade Item Number

SKU	GTIN
E0276-500G	04061833619704
E0276-25G	04061833512289
E0276-100G	04061833610657

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