E0377

D-Erythrose 4-phosphate sodium salt

• Synonym(s): 4-Phospho-D-erythrose sodium salt
• Empirical Formula (Hill Notation): C₄H₈NaO₇P
• CAS Number: 103302-15-4
• Molecular Weight: 222.07
• NACRES: NA.25

Properties

• Assay: ≥50% (TLC)
• Quality Level: 100
• form: powder
• storage temp.: −20°C
• SMILES string: [Na+].[H]C(=O)[C@H](O)[C@H](O)COP(O)([O-])=O
• InChI: 1S/C4H9O7P.Na/c5-1-3(6)4(7)2-11-12(8,9)10;/h1,3-4,6-7H,2H2,(H2,8,9,10);/q;+1/p-1/t3-,4+;/m0./s1
• InChI key: KKDBADMPNGAKHM-RFKZQXLXSA-M

Description

Application

D-Erythrose 4-phosphate (E4P) is used as a substrate to identify, differentiate and characterize 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase(s) and 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) synthase(s) that initiate the shikimate pathway in microorganisms and plants. It may be used as a substrate to identify, differentiate and characterize glyceraldehyde-3-phosphate dehydrogenase(s) (GAPDH) involved in surface antigen and virulence factor development in pathogenic microorganisms. E4P may be used in malaria research as an inhibitor of the PfPdx1 component of the PLP (pyridoxal 5′-phosphate) synthase enzymatic complex responsible for the de novo synthesizes vitamin B6 in Plasmodium falciparum.

Biochem/physiol Actions

Erythrose 4-phosphate is an intermediate in the penntose phosphate pathway, as well as the biosynthesis of phenylalanine, tyrosine, tryptophan and metabolism of vitamin B6.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable