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E0518

Sigma-Aldrich

C1 Esterase Inhibitor from human plasma

aqueous solution, ≥95% (SDS-PAGE)

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Synonym(s):
Complement C1 esterase inhibitor, Esterase inhibitor C-1 from human plasma
CAS Number:
MDL number:
NACRES:
NA.77

biological source

human plasma

Quality Level

Assay

≥95% (SDS-PAGE)

form

aqueous solution

mol wt

~105 kDa
~105 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SERPING1(710)

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This Item
A9024SRP3318A2221
Sigma-Aldrich

Sigma-Aldrich

SRP3318

C1 Inhibitor human

assay

≥95% (SDS-PAGE)

assay

≥70% protein basis (biuret)

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

aqueous solution

form

salt-free, lyophilized powder

form

lyophilized

form

lyophilized powder

mol wt

~105 kDa

mol wt

-

mol wt

52.8 kDa

mol wt

-

shipped in

dry ice

shipped in

-

shipped in

wet ice

shipped in

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

Esterase inhibitor C1 is a multifunctional regulator of all major kinin-generating protein cascade systems. It has been a therapeutic tool in the treatment of hereditary angioedema and complement-mediated inflammatory tissue damage such as capillary leak syndrome, septic shock, multiple organ failure, and hyperacute graft rejection.

Physical form

Solution in 20 mM potassium phosphate, pH 7.0, containing 250 mM KCl

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Xiaoxiao Hao et al.
Frontiers in immunology, 13, 816640-816640 (2022-02-19)
Periodontitis is a dysbiotic infectious disease that leads to the destruction of tooth supporting tissues. There is increasing evidence that periodontitis may affect the development and severity of Alzheimer's disease (AD). However, the mechanism(s) by which periodontal infection impacts the
A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond.
Medley, et al.
The Journal of biological chemistry, 298, 102439-102439 (2023)

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