The solubility of this product in water has not been determined. However, various sources report a solubility rate of 3.6 - 3.9 mg/L in water. Please see the link below to review these sources from PubChem:
https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol#section=Solubility
E1132
17β-Estradiol
ER agonist
Synonym(s):
1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
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About This Item
Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
Molecular Weight:
272.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352104
EC Number:
200-023-8
MDL number:
Beilstein/REAXYS Number:
1914275
Quality level:
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Product Name
β-Estradiol, analytical standard
InChI key
VOXZDWNPVJITMN-ZBRFXRBCSA-N
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
SMILES string
O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
grade
analytical standard
packaging
vial of 250 mg
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
176-180 °C (lit.)
application(s)
pharmaceutical
Quality Level
Gene Information
human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
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This Item | E2257 | PHR1353 | E2758 |
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) cell culture | mammalian: suitable, single cell analysis: suitable |
| grade analytical standard | grade - | grade certified reference material, pharmaceutical secondary standard | grade - |
| packaging vial of 250 mg | packaging - | packaging - | packaging - |
| mp 176-180 °C (lit.) | mp 176-180 °C (lit.) | mp 176-180 °C (lit.) | mp 176-180 °C (lit.) |
| application(s) pharmaceutical | application(s) - | application(s) pharmaceutical (small molecule) | application(s) - |
Biochem/physiol Actions
The major estrogen secreted by the premenopausal ovary.
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
Packaging
Supplied in amber screw-cap vials
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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H R Andersen et al.
Environmental health perspectives, 107 Suppl 1, 89-108 (1999-05-07)
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens, compounds with estrogenic metabolites
Yun Zhu et al.
PloS one, 12(2), e0171390-e0171390 (2017-02-06)
Mammalian lignans or enterolignans are metabolites of plant lignans, an important category of phytochemicals. Although they are known to be associated with estrogenic activity, cell signaling pathways leading to specific cell functions, and especially the differences among lignans, have not
Nobutada Sakagami et al.
The Journal of veterinary medical science, 76(10), 1403-1405 (2014-07-01)
The influences of glucose supplementation on early development of bovine embryos in BSA-free synthetic oviduct fluid were examined. Among the groups supplemented with 1.5, 2.0, 4.0 or 5.6 mM glucose either at 0, 72 or 144 hr after fertilization, blastocysts
Sarah B Putman et al.
PloS one, 10(10), e0140373-e0140373 (2015-10-16)
Because of poor reproduction after the lifting of an 8-year breeding moratorium, a biomedical survey of female lions in U.S. zoos was initiated in 2007. Fecal estrogen (FEM), progestagen (FPM) and glucocorticoid (FGM) metabolites were analyzed in samples collected 3-4
Hirotaka Ishii et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 13(4), 323-334 (2007-07-24)
It is believed that sex hormones are synthesized in the gonads and reach the brain via the blood circulation. In contrast with this view, the authors have demonstrated that sex hormones are also synthesized locally in the hippocampus and that
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