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E1530

Sigma-Aldrich

Anti-phospho-Epidermal Growth Factor Receptor (pTyr1086) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):
Anti-phospho-EGFR (pTyr1086)
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~185 kDa

species reactivity

human, mouse, rat

technique(s)

western blot: 1:1,000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... EGFR(1956)
mouse ... Egfr(13649)

Immunogen

synthetic phosphopeptide derived from the region of EGFR that contains tyrosine 1086.

Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1086 is a minor autophosphorylation site and enables the internalization of the receptor.

Physical form

Solution in Dulbecco′s phosphate buffered saline without Mg2+ and Ca2+, pH 7.3 with 50% glycerol, 1 mg/mL BSA (protease and IgG free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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