MilliporeSigma
All Photos(3)

Documents

E4876

Sigma-Aldrich

17α-Ethynylestradiol

≥98%

Sign Into View Organizational & Contract Pricing

Synonym(s):
17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol, Ethinylestradiol
Empirical Formula (Hill Notation):
C20H24O2
CAS Number:
Molecular Weight:
296.40
Beilstein/REAXYS Number:
2419975
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

sterility

non-sterile

assay

≥98%

form

powder

mp

182-183 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key

BFPYWIDHMRZLRN-SLHNCBLASA-N

Gene Information

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
E19000001260001BP421
vibrant-m

E4876

17α-Ethynylestradiol

vibrant-m

E1900000

Ethinylestradiol

vibrant-m

1260001

Ethinyl estradiol

vibrant-m

BP421

Ethinylestradiol

assay

≥98%

assay

-

assay

-

assay

-

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

2-8°C

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

solubility

-

solubility

-

solubility

-

shipped in

ambient

shipped in

-

shipped in

-

shipped in

-

biological source

synthetic

biological source

-

biological source

-

biological source

-

General description

17α-Ethynylestradiol (EE2) is a synthetic hormone. It is a derivative of estradiol (E2). It is implicated in estrogen replacement therapy and suspension of breastfeeding. EE2 is used to treat osteoporosis, menopausal and postmenopausal syndrome. It is also used to treat prostatic cancer and breast cancer in postmenopausal women. EE2 functions as an endocrine-disrupting chemical (EDC).

Application

17α-Ethynylestradiol has been used to study the effect of exogenous estrogen and selective estrogen receptor modulator (SERM) in rats. It also has been used to increase the concentration of low density lipoprotein (LDL) receptor in rabbit liver.

Biochem/physiol Actions

17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 7

1 of 7

α-Estradiol powder, ≥98% (TLC)

Sigma-Aldrich

E8750

α-Estradiol

Estriol ≥97%

Sigma-Aldrich

E1253

Estriol

19-Norethindrone ≥98%, powder

Sigma-Aldrich

N4128

19-Norethindrone

Dienogest ≥98% (HPLC)

Sigma-Aldrich

SML1468

Dienogest

Levonorgestrel Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1850

Levonorgestrel

Analysis of 17-beta-estradiol and 17-alpha-ethinylestradiol in biological and environmental matrices?a review
Barreiros L, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 126, 243-262 (2016)
Purification of low density lipoprotein receptor from liver and its quantification by anti-receptor monoclonal antibodies
Gherardi E, et al.
The Biochemical Journal, 253(2), 409-415 (1988)
Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application
Hoegh-Andersen P, et al.
Arthritis Research & Therapy, 6(2), R169-R169 (2004)
Occurrence of 17alpha-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review
Aris AZ, et al.
Environment International, 69, 104-119 (2014)
Huda Omar Ali et al.
PloS one, 11(3), e0152114-e0152114 (2016-03-22)
Oestrogens influence the pathology and development of hormone-sensitive breast cancers. Tissue factor pathway inhibitor (TFPI) has been shown to be associated with breast cancer pathogenesis. Recently, we found TFPI mRNA levels to be significantly reduced by oestrogens in a breast

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service