E6402

Sigma-Aldrich

Elastin from mouse lung

powder

CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

Quality Level

biological source

mouse lung

form

powder

UniProt accession no.

storage temp.

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Gene Information

mouse ... Eln(13717)

General description

Elastin is a key protein of the extracellular matrix (ECM). It is made up of glycoproteins, glycosaminoglycans, collagen and proteoglycans. Elastin is mainly localized in the arteries and lungs.
Elastin is an important extracellular matrix (ECM) protein derived from its precursor tropoelastin. Elastin is highly flexible than collagen.

Application

Elastin mouse lung has been used as an extracellular matrix (ECM) protein for coating of plates.

Biochem/physiol Actions

Elastin delivers elasticity to tissues and organs. In addition, it is also involved in paracrine signaling. Genetic variation in the gene coding for elastin causes Williams-Beuren syndrome, cutis laxa and supravalvular aortic stenosis (SVAS).
Elastin plays an important role in the elasticity and resilience of many tissues, such as ligament, tendon and elastic cartilage. It is also involved in the elasticity of large arteries and skin.
Elastin plays a critical role in alveolization in the fetal lung. In vivo radiochemical labelling indicates that mouse or rat lung elastin is synthesized primarily prenatally and during the first two weeks of life. It turns over very slowly, with a half-life estimated at several years.

Preparation Note

Purified under mild extraction conditions to minimize peptide bond cleavage as described by Starcher, et al.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Jiří Kanta
Frontiers in physiology, 7, 491-491 (2016-11-09)
A characteristic feature of liver cirrhosis is the accumulation of large amounts of connective tissue with the prevailing content of type I collagen. Elastin is a minor connective tissue component in normal liver but it is actively synthesized by hepatic...
Elastin in the Liver
Kanta J.
Frontiers in Physiology, 7, 491-491 (2016)
Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model
Hinton RB, et al.
Circulation Research, 107(4), 549-557 (2010)
Elastin
Biochemistry of Collagens, Laminins and Elastin, 290(2), 197-201 (2016)
An experimental system to study mechano transduction in fetal lung cells
Wang Y, et al.
Journal of Visualized Experiments, 7(60), e3543-e3543 (2012)

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