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E6530

Sigma-Aldrich

Etomidate

>98% (HPLC), powder

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Synonym(s):
(R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester, Amidate, R16659
Empirical Formula (Hill Notation):
C14H16N2O2
CAS Number:
Molecular Weight:
244.29
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

>98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

CCOC(=O)c1cncn1[C@H](C)c2ccccc2

InChI

1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1

InChI key

NPUKDXXFDDZOKR-LLVKDONJSA-N

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This Item
1268750SML2295SML1391
Etomidate >98% (HPLC), powder

Sigma-Aldrich

E6530

Etomidate

Etomidate United States Pharmacopeia (USP) Reference Standard

USP

1268750

Etomidate

Dimethyoxy-etomidate ≥98% (HPLC)

Sigma-Aldrich

SML2295

Dimethyoxy-etomidate

Olmesartan medoxomil ≥98% (HPLC)

Sigma-Aldrich

SML1391

Olmesartan medoxomil

form

powder

form

-

form

oil

form

powder

color

white

color

-

color

colorless to light brown

color

white to beige

solubility

DMSO: >10 mg/mL

solubility

-

solubility

-

solubility

DMSO: 10 mg/mL, clear

originator

Johnson & Johnson

originator

-

originator

-

originator

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Etomidate is an imidazole derivative, which functions as an nonbarbiturate hypnotic agent. It is used in speech and memory test. Etomidate regulates hemodynamic stability by preserving sympathetic outflow and autonomic reflexes. It inhibits adrenal steroidogenesis.

Biochem/physiol Actions

Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Beatrice de la Grandville et al.
European journal of anaesthesiology, 29(11), 511-514 (2012-09-12)
Etomidate is an imidazole-derived hypnotic agent preferentially used for rapid sequence induction of anaesthesia because of its favourable haemodynamic profile. However, 11β-hydroxylase inhibition causes adrenal insufficiency with potentially fatal consequences in specific populations. We review the arguments against the liberal
A Möller Petrun et al.
British journal of anaesthesia, 110(3), 388-396 (2012-11-21)
In a double-blind, randomized trial, we compared the haemodynamic effects of a bispectral index (BIS)-guided etomidate and propofol infusion for anaesthesia induction in patients undergoing major abdominal surgery. Forty-six patients were randomly assigned to two groups based on the induction
Inhibition of adrenal steroidogenesis by the anesthetic etomidate
Wagner RL, et al.
The New England Journal of Medicine, 310(22), 1415-1421 (1984)
Karla Kretschmannova et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(17), 7264-7273 (2013-04-26)
Intravenous anesthetics exert a component of their actions via potentiating inhibitory neurotransmission mediated by γ-aminobutyric type-A receptors (GABAARs). Phasic and tonic inhibition is mediated by distinct populations of GABAARs, with the majority of phasic inhibition by subtypes composed of α1-3βγ2
Sympathetic responses to induction of anesthesia in humans with propofol or etomidate.
Ebert TJ, et al.
Anesthesiology, 76(5), 725-733 (1992)

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