synthetic peptide corresponding to amino acids 477-493 of human EZH2, conjugated to KLH via a C-terminal added cysteine residue.
Anti-EZH2 antibody produced in rabbit is suitable for indirect immunofluorescence at a dilution of 1:500-1:1,000 using HEK-293T cells fixed with paraformaldehyde-triton and for western blotting at a dilution of 1:500-1:1,000 using K562 cell lysates.
Histone-lysine N-methyltransferase EZH2 is an enzyme encoded by the EZH2 gene in humans. It belongs to the multiprotein polycomb repressive complex 2. Enhancer of zeste homologue 2 (EZH2) is crucially involved in epigenetic silencing by acting as a histone methyltransferase. It is overexpressed in many cancers and is involved in malignant cell proliferation and invasion. EZH2 may be associated with senescence and apoptosis in gastric cancer. It may act as a valuable biomarker for the diagnosis and prognosis of gastric cancer. EZH2 may have function in regulation of gene transcription and chromatin structure.
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
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