EZH2 gene is mapped to human chromosome 7q36.1.
Histone-lysine N-methyltransferase EZH2 is an enzyme encoded by the EZH2 gene in humans. It belongs to the multiprotein polycomb repressive complex 2.
Anti-EZH2 (N-terminal) recognizes human and mouse EZH2.
synthetic peptide corresponding to amino acids 1-14 of human EZH2.
Anti-EZH2 (N-terminal) antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and immunoblotting
Anti-EZH2 (N-terminal) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:1,000 using K562 cell lysates and NIH3T3 cell lysates.
Mutations in the EZH2 gene is implicated in the congenital disorder, Weaver syndrome.
Enhancer of zeste homologue 2 (EZH2) is crucially involved in epigenetic silencing by acting as a histone methyltransferase. It is overexpressed in many cancers and is involved in malignant cell proliferation and invasion. EZH2 may be associated with senescence and apoptosis in gastric cancer. It may act as a valuable biomarker for the diagnosis and prognosis of gastric cancer. EZH2 may have function in regulation of gene transcription and chromatin structure.
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.