MilliporeSigma
All Photos(3)

E7138

Sigma-Aldrich

Ethosuximide

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
2-Ethyl-2-methylsuccinimide
Empirical Formula (Hill Notation):
C7H11NO2
CAS Number:
Molecular Weight:
141.17
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

solubility

ethanol: 100 mg/mL

originator

Pfizer

SMILES string

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

Inchi Key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Gene Information

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
E2150000PHR1413E101
Ethosuximide

Sigma-Aldrich

E7138

Ethosuximide

Ethosuximide European Pharmacopoeia (EP) Reference Standard

E2150000

Ethosuximide

Ethosuximide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1413

Ethosuximide

originator

Pfizer

originator

-

originator

-

originator

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

100

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Gene Information

human ... DRD2(1813)

Application

Ethosuximide has been used:
  • to confirm its effect on spike wave discharges (SWD) in rats
  • to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
  • as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 7

1 of 7

Lamotrigine ≥98%, powder

Sigma-Aldrich

L3791

Lamotrigine

5,5-Diphenylhydantoin ≥98%

Sigma-Aldrich

D4007

5,5-Diphenylhydantoin

(±)-Vigabatrin

Sigma-Aldrich

V8261

(±)-Vigabatrin

Pentylenetetrazole

Sigma-Aldrich

P6500

Pentylenetetrazole

Gabapentin solid

Sigma-Aldrich

G154

Gabapentin

Levetiracetam ≥98% (HPLC)

Sigma-Aldrich

L8668

Levetiracetam

Clonazepam powder

Sigma-Aldrich

C1277

Clonazepam

Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce PS, et al.
Epilepsy & Behavior : E&B, 32, 121-131 (2014)
Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo
Huang HY, et al.
Journal of Materials Chemistry, 22(17), 8566-8573 (2012)
Behavioural responses of zebrafish larvae to acute ethosuximide exposure
Ji Y, et al.
Behavioural Pharmacology, 28(6), 428-440 (2017)
N Leresche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4842-4853 (1998-06-23)
The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In thalamocortical (TC) neurons of the
Meng-Hsuan Hsiao et al.
Journal of controlled release : official journal of the Controlled Release Society, 161(3), 942-948 (2012-06-02)
Thermo-gelling injectable nanogels, with no burst release of loaded drug, were prepared by a simple route by combining self assembled nanocapsules of amphiphilically modified chitosan with glycerophosphate di-sodium salt and glycerol. The potential as a depot drug delivery system was

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service