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E7153

Sigma-Aldrich

Anti-phospho-ERK5 (pThr218/pTyr220) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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Synonym(s):
Anti-BMK1
EC Number:
MDL number:
NACRES:
NA.44

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAPK7(5598)

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J4644RAB0350RAB0352
Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

-

biological source

rabbit

biological source

rabbit

biological source

-

biological source

-

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

-

form

-

Gene Information

human ... MAPK7(5598)

Gene Information

human ... MAPK8(5599)

Gene Information

human ... MAPK1(5594), MAPK3(5595)
mouse ... MAPK1(26413), MAPK3(26417)
rat ... MAPK1(16590), MAPK3(50689)

Gene Information

human ... MAPK1(5594), MAPK14(1432), MAPK3(5595), MAPK8(5599)
mouse ... MAPK1(26413), MAPK14(26416), MAPK3(26417), MAPK8(26419)
rat ... MAPK1(116590), MAPK14(81649), MAPK3(50689), MAPK8(116554)

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General description

Extracellular Signal-Regulated Kinases (ERKs) are proteins that belong to mitogen-activated protein kinase superfamily (MAPK) and have a pivotal role in cell cycle, differentiation, transcription and learning and memory through signal transduction in the cytoplasm and the nucleus. ERK5 MAP kinase cascade has a crucial functions like- induction of special form of cardiac hypertrophy, enhanced neuronal survival and early steps of muscle cell differentiation. Anti-phospho-ERK5 (pThr218/pTyr220) antibody can be used in immunostaining. Rabbit anti- phospho-ERK5 (pThr218/pTyr220) antibody reacts specifically with ERK5 (88 kD) of human.

Immunogen

Synthetic phosphopeptide derived from the region of human ERK5 that contains threonine 218 and tyrosine 220. This sequence is conserved in human and mouse.

Application

Each vial contains enough material for 10 blots. The end user should determine the correct working dilution for their process.

Physical form

Solution in Dulbecco′s PBS, pH 7.3, with 50% glycerol, 1 mg/ml BSA and ≤ 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Congde Chen et al.
Aging, 11(2), 697-706 (2019-01-27)
Diabetic patients are prone to developing Alzheimer's disease (AD), in which microglia play a critical role. However, the direct effect of high glucose (HG) on microglia and the role of extracellular-signal-regulated kinase 5 (ERK5) signaling in this interaction have not
Kaoru Toshima et al.
International immunology, 31(4), 211-223 (2018-12-19)
Sphingomyelin (SM) in combination with cholesterol forms specialized membrane lipid microdomains in which specific receptors and signaling molecules are localized or recruited to mediate intracellular signaling. SM-microdomain levels in mouse thymus were low in the early CD4+CD8+ double-positive (DP) stage
Suji Kim et al.
Scientific reports, 8(1), 15172-15172 (2018-10-13)
Recent studies have indicated that protease-activated receptor-1 (PAR-1) is involved in cytoprotective and anti-inflammatory responses in endothelial cells (ECs). However, the role of PAR-1 in laminar flow-mediated atheroprotective responses remains unknown. Herein, we investigated whether PAR-1 regulates laminar flow-mediated mechanotransduction
Mahmud Hasan et al.
Molecular pharmacology, 96(2), 272-296 (2019-06-22)
Tamoxifen is used to prevent and treat estrogen receptor-positive (ER+) breast cancer (BC); however, its chronic use can increase uterine cancer risk and induce tamoxifen resistance. Novel melatonin-tamoxifen drug conjugates may be promising to treat BC and may help offset
Rajinder S Sawhney et al.
Journal of cellular physiology, 219(1), 152-161 (2008-12-18)
In metastatic cancer, high expression levels of vitronectin (VN) receptors (integrins), FAK, and ERK5 are reported. We hypothesized that integrin-mediated ERK5 activation via FAK may play a pivotal role in cell adhesion, motility, and metastasis. ERK5 and FAK phosphorylation when

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