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This compound can be dissolved in DMSO, where it should be soluble to a concentration of 30 mg/mL.
E7384
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt
≥97% (HPLC), μ-opioid receptors agonist
Synonym(s):
DAGO, DAMGO, Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol
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E7384-1MG
$69.30
E7384-5MG
$225.00
E7384-10MG
$385.00
E7384-50MG
$1,309.00
About This Item
Empirical Formula (Hill Notation):
C26H35N5O6
CAS Number:
Molecular Weight:
513.59
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
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Product Name
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CC(O)=O.C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc2ccccc2)C(=O)NCCO
InChI
1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36);1H3,(H,3,4)/t17-,21+,22+;/m1./s1
InChI key
XZZYKCKUDLGXJA-NJUGUJQKSA-N
Gene Information
human ... OPRM1(4988)
mouse ... OPRM1(18390)
rat ... OPRM1(25601)
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Related Categories
1 of 4
This Item | E7131 | M6638 | L9133 |
|---|---|---|---|
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥95.0% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... OPRM1(4988) | Gene Information human ... OPRD1(4985) | Gene Information human ... OPRD1(4985), OPRM1(4988) | Gene Information human ... OPRD1(4985), OPRM1(4988) |
Amino Acid Sequence
Tyr-Ala-Gly-Nme-Phe-Gly-ol
General description
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the μ-opioid receptor.[1] μ-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as β-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone.[2]
Application
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO has been used:
- for use as a positive control in the assay of G-protein activation with μ-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO [1]
- for the determination of the suppression of contraction by opioid receptors [3]
- to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats [4]
Biochem/physiol Actions
Enkephalin analog that is a selective agonist at μ-opioid receptors.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Frank J Meye et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(46), 16120-16128 (2012-11-16)
μ-Opioid receptors (MORs) in the ventral tegmental area (VTA) are pivotally involved in addictive behavior. While MORs are typically activated by opioids, they can also become constitutively active in the absence of any agonist. In the current study, we present
Raza Qazi et al.
Nature biomedical engineering, 3(8), 655-669 (2019-08-07)
Both in vivo neuropharmacology and optogenetic stimulation can be used to decode neural circuitry, and can provide therapeutic strategies for brain disorders. However, current neuronal interfaces hinder long-term studies in awake and freely behaving animals, as they are limited in
Javier Llorente et al.
The European journal of neuroscience, 36(12), 3636-3642 (2012-09-26)
There is considerable controversy over whether μ-opioid receptor (MOPr) desensitization is homologous or heterologous and over the mechanisms underlying such desensitization. In different cell types MOPr desensitization has been reported to involve receptor phosphorylation by various kinases, including G-protein-coupled receptor
Ken W K Lee et al.
Journal of psychiatry & neuroscience : JPN, 40(1), 38-45 (2014-10-01)
Preference for fatty foods is a risk factor for obesity. It is a complex behaviour that involves the brain reward system and is regulated by genetic and environmental factors, such as the opioid receptor mu-1 gene (OPRM1) and prenatal exposure
Roberta Lattanzi et al.
Frontiers in pharmacology, 9, 1002-1002 (2018-09-21)
Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs. Opioids are the mainstay for the treatment of
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DAMGO Acetate salt를 H2O에 녹이라고 되어있는데, 이를 DMSO에 녹여서 사용해도 괜찮을까요? Specification sheets says to dissolve DAMGO Acetate salt in H2O, is it okay to dissolve it in DMSO?
1 answer-
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