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MilliporeSigma

EHU050581

MISSION® esiRNA

targeting human NEK7

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$242.00

50 μG

$435.00

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324

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Product Name

MISSION® esiRNA, targeting human NEK7

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TGGGGTGGTAAAACTTGGAGATCTTGGGCTTGGCCGGTTTTTCAGCTCAAAAACCACAGCTGCACATTCTTTAGTTGGTACGCCTTATTACATGTCTCCAGAGAGAATACATGAAAATGGATACAACTTCAAATCTGACATCTGGTCTCTTGGCTGTCTACTATATGAGATGGCTGCATTACAAAGTCCTTTCTATGGTGACAAAATGAATTTATACTCACTGTGTAAGAAGATAGAACAGTGTGACTACCCACCTCTTCCTTCAGATCACTATTCAGAAGAACTCCGACAGTTAGTTAATATGTGCATCAACCCAGATCCAGAGAAGCGACCAGACGTCACCTATGTTTATGACGTAGCAAAGAGGATGCATGCATGCACTGCAAGCAGCTAAACATGCAA

Ensembl | human accession no.

ENSG00000151414

NCBI accession no.

NM_133494

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

human ... NEK7(140609), NEK7(140609)

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MISSION® esiRNA targeting human NEK7

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MISSION® esiRNA

MISSION® esiRNA targeting human SRXN1, RP5-850E9.3

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EHU093691

MISSION® esiRNA

MISSION® esiRNA targeting human NEK6

Sigma-Aldrich

EHU072251

MISSION® esiRNA

MISSION® esiRNA targeting human NEK4

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EHU136371

MISSION® esiRNA

esiRNA cDNA target sequence

TGGGGTGGTAAAACTTGGAGATCTTGGGCTTGGCCGGTTTTTCAGCTCAAAAACCACAGCTGCACATTCTTTAGTTGGTACGCCTTATTACATGTCTCCAGAGAGAATACATGAAAATGGATACAACTTCAAATCTGACATCTGGTCTCTTGGCTGTCTACTATATGAGATGGCTGCATTACAAAGTCCTTTCTATGGTGACAAAATGAATTTATACTCACTGTGTAAGAAGATAGAACAGTGTGACTACCCACCTCTTCCTTCAGATCACTATTCAGAAGAACTCCGACAGTTAGTTAATATGTGCATCAACCCAGATCCAGAGAAGCGACCAGACGTCACCTATGTTTATGACGTAGCAAAGAGGATGCATGCATGCACTGCAAGCAGCTAAACATGCAA

esiRNA cDNA target sequence

CCCTCATGGAGCTAAGGTCAGCTGTTACCTCAGCTGGGCCTGGATGGTCTAGGATAGCCTTACTCACTTGCCTGGCAGGTGACAGGCTGTTGGCTGGAATTGCTTGGTTCTCCTCCATGTGGCCTCTCCAGCAGGCTAGCTCAGGCTTATTCACATGATGGCTTCAGGATTCCAAAGAGAGTGAGAGTAGAAGCTGAAAGACTTCTTGAGTTCTTGGCCTGGAACTGGGACTAGGACAGTGTCACTTCTGCTAAGTTCTTTTGGTCAGAGCAAATCACAAGGCTTTACCCAGATTCAAGGGATGAGAAACAGACTACATGTCTTGATGAGGGGAACCACAAAGAGCTTGTGGCCATTTTTCACCT

esiRNA cDNA target sequence

TCTTCTCCTGGACACCTGCTGTGTACCAGGAACTTCGTCACCTCCTTGAATGCTGGCGGTTCATTTCATGATCAGTGTTAAGCATTTTCCTCCATGGGAAGGAAGCATGGGATATAGAAAAGCGAAGGGCTGTCCTTTACAAATTCTGGTTCTGCAACTTCCTAGCGTGACTTTGGGCTTGGGCAAGTTTCTTAGCCGTTCTGAGCCTTCATTTCCTCATCTGTACAATGAGATTAATAGTACCTATCATCTACCTTCAGGATTGCTGACAGACAGAATTTGAAATAAAATATGCAAGTTAGCTAATACAAAAAGTAGATGATCCAAAAATGGTAGCCACTCACCCTTCACAAACTGAAGTCCATGGACCACGGAAGTCGAGAATTAATGTACACCTGTATCATGTGTAGGAAACCAGAAATGTGTTCCTTATTTCTTGTTCCCAAACAGGA

esiRNA cDNA target sequence

TCAGTTGAAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTACATTGTCATGGGCTTCTGTGAAGGAGGTGATTTGTACCGAAAGCTCAAGGAGCAGAAAGGGCAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTGTACAGATCGCCATGGCTTTGCAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAAACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCAAACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGAAG

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Gene Information

human ... NEK7(140609), NEK7(140609)

Gene Information

human ... SRXN1(140809), SRXN1(140809)

Gene Information

human ... NEK6(10783), NEK6(10783)

Gene Information

human ... NEK4(6787), NEK4(6787)

Ensembl | human accession no.

ENSG00000151414

Ensembl | human accession no.

ENSG00000172070

Ensembl | human accession no.

ENSG00000119408

Ensembl | human accession no.

ENSG00000114904

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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JUU
MCT
NRR
RPR

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Gen Li et al.
Frontiers in neurology, 11, 551-551 (2020-08-01)
Background: Subarachnoid hemorrhage (SAH) is a devastating disease which leads to high morbidity and mortality. Recent studies have indicated that, never in mitosis gene A-related expressed kinase 7 (NEK7), is involved in NLRP3 (NLR family, pyrin domain containing 3) associated
Huan Liu et al.
Biochemical pharmacology, 177, 113998-113998 (2020-05-01)
Disordered immune regulation and persistent inflammatory damage are the key mechanisms of ventilator-induced lung injury (VILI). NLR family pyrin domain containing 3 (NLRP3) inflammasome activation causes VILI by mediating the formation of inflammatory mediators and infiltration of inflammatory cells, increasing
Yuan Yue et al.
Cell death & disease, 9(9), 904-904 (2018-09-07)
The molecular mechanisms underlying the severe lung pathology that occurs during SARS-CoV infections remain incompletely understood. The largest of the SARS-CoV accessory protein open reading frames (SARS 3a) oligomerizes, dynamically inserting into late endosomal, lysosomal, and trans-Golgi-network membranes. While previously
Ana Tapia-Abellán et al.
Nature chemical biology, 15(6), 560-564 (2019-05-16)
NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is an innate immune sensor that contributes to the development of different diseases, including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer's disease. The molecule sulfonylurea MCC950 is a NLRP3 inflammasome inhibitor with potential

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