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EHU095251

Sigma-Aldrich

MISSION® esiRNA

targeting human MUC1

All Photos(1)
NACRES:
NA.51

description

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Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

AGTTCAGGCCAGGATCTGTGGTGGTACAATTGACTCTGGCCTTCCGAGAAGGTACCATCAATGTCCACGACGTGGAGACACAGTTCAATCAGTATAAAACGGAAGCAGCCTCTCGATATAACCTGACGATCTCAGACGTCAGCGTGAGTGATGTGCCATTTCCTTTCTCTGCCCAGTCTGGGGCTGGGGTGCCAGGCTGGGGCATCGCGCTGCTGGTGCTGGTCTGTGTTCTGGTTGCGCTGGCCATTGTCTATCTCATTGCCTTGGCTGTCTGTCAGTGCCGCCGAAAGAACTACGGGCAGCTG

Ensembl | human accession no.

ENSG00000185499

NCBI accession no.

NM_001044392

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... MUC1(4582) , MUC1(4582)

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MISSION® esiRNA targeting human MUC1

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MISSION® esiRNA targeting human MUM1 (2)

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EHU099871

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MISSION® esiRNA targeting human MUM1 (1)

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EHU098141

MISSION® esiRNA

MISSION® esiRNA targeting human MUC7

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EHU039201

MISSION® esiRNA

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

esiRNA cDNA target sequence

AGTTCAGGCCAGGATCTGTGGTGGTACAATTGACTCTGGCCTTCCGAGAAGGTACCATCAATGTCCACGACGTGGAGACACAGTTCAATCAGTATAAAACGGAAGCAGCCTCTCGATATAACCTGACGATCTCAGACGTCAGCGTGAGTGATGTGCCATTTCCTTTCTCTGCCCAGTCTGGGGCTGGGGTGCCAGGCTGGGGCATCGCGCTGCTGGTGCTGGTCTGTGTTCTGGTTGCGCTGGCCATTGTCTATCTCATTGCCTTGGCTGTCTGTCAGTGCCGCCGAAAGAACTACGGGCAGCTG

esiRNA cDNA target sequence

GGGAGTACGTTGTGCCAAATCATTGCCACTTGCCACATGAGTGTAAATGATGGCGGATGCTATGTCCTCTGCCGATGGGAAAAGCGATTATGGCCTGCGAAGGTTTTGGCCCGAACCGCGACTTCAACAAAAAATAAGAGAAGAAAGGAATATTTTCTAGCTGTGCAAATCCTCTCTCTAGAGGAAAAAATTAAGGTGAAAAGCACTGAAGTTGAGATCCTAGAGAAGTCTCAAATTGAAGCCATTGCTTCCTCGTTAGCCTCACAGAATGAGGTTCCTGCGGCACCCCTGGAAGAACTGGCCTACAGACGGTC

esiRNA cDNA target sequence

AAAGGACGGAAGCGTATTCACTGTGCGCCAGTACTCCTGGCTGTGCTGTGGTTTCTCCCGACGTGCACATCGATCTCGTATGTGTGGCATCTGATATTAAACGGGAGGTTTTAAGAAGCGTCTGCCGTGATCATGGAGCTTCGGAAGCGGGAATGGTTCTTCCGGGTTTGCTGTTTTGTCTGTTTCCCCCTTGTGTGGTTTCCGCCTGCGACAGTTCCAGAATTTGCTCTCCCACTCAGTGTGCTCTGCAGCTGTGAGGAAACAGCCTTCGTTAGAGGCGGGAGCAGAGACGAGCCGCTGCTCTGTGTCGTGTTTGCTGTG

esiRNA cDNA target sequence

CAGCTCCTGGCCAAAATAAAATTTCTCGATTTCTTTTATATATGAAGAATCTACTAAACAGAATTATTGACGACATGGTGGAGCAATAGTATATTGTATGTTGTAAAGTGTTCTGTCATTTACAAGATGTGATTCATGAGTGCAGAACTACCACCTTTCTTTTAGCACCAATCCCAACATGAAATTATATTACTCAGATTTAAAGCACTATCATTAATCTTTCAATCTAATTATTCACCACCACAAGACCTATTAACAAGACAAAATGCCTCTATCCCACAAGCCAGATGCAGGTCTGGGGTTCAAAATAACTCTTTGGATCCTACAGAGATAGCCTACTGAGGGCAAAGAAAGTCCTTAGATAAAGAGAGAATATTGTATGGGCCATCAACCATTTACTTTTCCCTGAATGTTAGAAACTACAAAACCACTACCTTGTACCCCCATCAAAATCCCACCTGAACCAT

Ensembl | human accession no.

ENSG00000185499

Ensembl | human accession no.

ENSG00000160953

Ensembl | human accession no.

ENSG00000160953

Ensembl | human accession no.

ENSG00000171195

NCBI accession no.

NM_001044392

NCBI accession no.

NM_032853

NCBI accession no.

NM_032853

NCBI accession no.

NM_152291

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Ping Li et al.
International journal of clinical and experimental pathology, 8(9), 10365-10374 (2015-12-01)
Muc-1 is a member of the carbohydrate-binding protein family that contributes to neoplastic transformation, tumor survival, angiogenesis, and metastasis. The aim of this study is to investigate the role of muc-1 in human oral squamous cell carcinoma progression. In this
Satomi Shiba et al.
The Journal of surgical research, 238, 79-89 (2019-02-15)
Mucin1 (MUC1), a member of the mucin family, is a glycoprotein which is often expressed in malignant cells. However, the expression and function of MUC1 in human duodenal adenocarcinoma (DAC) has not yet been characterized because of its low frequency.
Mei Guo et al.
International immunopharmacology, 88, 106850-106850 (2020-08-11)
Targeted clearance of colorectal cancer stem cells (CCSCs) has become a novel strategy for tumor immunotherapy. Molecule mucin1 (MUC1) is one of targetable cell surface antigens in CCSCs. However, the critical role of MUC1 in anti-tumor effects of CCSC vaccine
Ashujit Tagde et al.
Oncotarget, 8(41), 69237-69249 (2017-10-21)
The polycomb repressive complex 1 (PRC1) includes the BMI1, RING1 and RING2 proteins. BMI1 is required for survival of multiple myeloma (MM) cells. The MUC1-C oncoprotein is aberrantly expressed by MM cells, activates MYC and is also necessary for MM
Dina Stroopinsky et al.
Journal of cellular and molecular medicine (2018-05-16)
Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with an unmet need for improved therapies. Responses to standard cytotoxic therapy in AML are often transient because of the emergence of chemotherapy-resistant disease. The MUC1-C oncoprotein governs critical pathways of
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