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MilliporeSigma

EHU109221

MISSION® esiRNA

targeting human TARDBP

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324

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description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ATGCCGAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGAAACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCAGCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTAGCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAGAGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGAC

Ensembl | human accession no.

ENSG00000120948

NCBI accession no.

NM_007375

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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EHU050851EHU060471EHU118631
MISSION® esiRNA targeting human TARDBP

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EHU109221

MISSION® esiRNA

MISSION® esiRNA targeting human SSBP2

Sigma-Aldrich

EHU050851

MISSION® esiRNA

MISSION® esiRNA targeting human WDR7

Sigma-Aldrich

EHU060471

MISSION® esiRNA

MISSION® esiRNA targeting human QPRT

Sigma-Aldrich

EHU118631

MISSION® esiRNA

esiRNA cDNA target sequence

ATGCCGAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGAAACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCAGCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTAGCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAGAGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGAC

esiRNA cDNA target sequence

CAAGAGGAATGGTGCCCTTAGGACCACAGAACTATGGAGGTGCAATGAGACCCCCACTGAATGCTTTAGGTGGCCCTGGAATGCCTGGAATGAACATGGGTCCAGGTGGTGGTAGACCTTGGCCAAACCCAACAAATGCCAATTCAATACCATACTCCTCAGCATCTCCTGGGAATTATGTAGGTCCTCCAGGAGGTGGAGGGCCACCAGGAACACCCATCATGCCTAGTCCAGCAGATTCAACCAACTCTGGTGATAACATGTATACTTTAATGAATGCAGTACCTCCTGGACCTAACAGACCTAATTTTCCAATGGGTCCTGGGTCAGATGGTCCCATGGGTGGATTAGGAGGAATGGAGTCACATCACATGAATGGCTCTTTAGGCTCAGGAGATATGGACAGTATTTCCAAGAATTCTCCCAATAATATGAGCCTGAGTAATCAACCG

esiRNA cDNA target sequence

TCAAAGTCTAGGAACAAACATTGGTTATTTCACTGAAACAGATTTTTAAAGAGCATATTAAGAAATTAAGACCATTAGATCATCTCTTTCATAATGATATGATGTTATTTCCATTGACGGCAAATCTATACTGTTCCTTGGTTTTAGAGTTGGGTATTCTTTCAAAAGTGAATTTAGGCACATGCATGTACATTGTATTTATAAAGATTATATATGTAGTTTCCAAGGAAGAAACAAAGACCTATACAGTTTAGACTTTATTTGTTTGGTGAACGTGCTGTTGTGTTTGGCATAGCTAGAGAAATGTAAGGTAAAAGGCTCACTTTGTTTTCCAGTGGGTCCAGAGTCTTCTCTATACCCAACATATGTTTACTTTATGAACTTAAATGGAAATTAATTTATTGTAGACTACATCTCTATTTGGAATGATGAGGTAAATGTATACCTTAGCATTTTCTTTAACAAAAATGTTCTGTGTGTCAGGAA

esiRNA cDNA target sequence

AAGGTGGAAGTGGAATGCAGCAGCCTGCAGGAGGCCGTGCAGGCAGCTGAGGCTGGTGCCGACCTTGTCCTGCTGGACAACTTCAAGCCAGAGGAGCTGCACCCCACGGCCACCGTGCTGAAGGCCCAGTTCCCGAGTGTGGCTGTGGAAGCCAGTGGGGGCATCACCCTGGACAACCTCCCCCAGTTCTGCGGGCCGCACATAGACGTCATCTCCATGGGGATGCTGACCCAGGCGGCCCCAGCCCTTGATTTCTCCCTCAAGCTGTTTGCCAAAGAGGTGGCTCCAGTGCCCAAAATCCACTAGTCCTAAACCGGAAGAGGATGACACCGGCCATGGGTTAACGTGGCTCCTCAGGACCCTCTGGGTCACACATCTTTAGGGTCAGTGGCCAATGGGGCACATTTGGCACTAGCTTGAGCCCAACTCTGGCTCTGCCACCTGCTGCTCCTGTGACCTGTCAGGGCTGACTTCACCTCTGCTCATCTCAGTTTCCTAATCTGTAAAATGGGTCTAATAAAGGATCAACCACATGGGGTTCTGCGGTGATAATGAGCAC

Ensembl | human accession no.

ENSG00000120948

Ensembl | human accession no.

ENSG00000145687

Ensembl | human accession no.

ENSG00000091157

Ensembl | human accession no.

ENSG00000103485

Gene Information

human ... TARDBP(23435), TARDBP(23435)

Gene Information

human ... SSBP2(23635), SSBP2(23635)

Gene Information

human ... WDR7(23335), WDR7(23335)

Gene Information

human ... QPRT(23475), QPRT(23475)

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

NCBI accession no.

NM_007375

NCBI accession no.

NM_012446

NCBI accession no.

NM_015285

NCBI accession no.

NM_014298

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Xiaowei Chen et al.
Protein & cell, 9(10), 848-866 (2017-09-28)
Aberrant regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a RNA/DNA binding protein associated with neurodegeneration, is involved in miRNA biogenesis. Here, we systematically examined
Seiichi Nagano et al.
Acta neuropathologica, 140(5), 695-713 (2020-08-18)
Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We
Michael E Ward et al.
The Journal of experimental medicine, 211(10), 1937-1945 (2014-08-27)
Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene
Alexander Gulliver Bjørnholt Grønning et al.
Nucleic acids research, 48(13), 7099-7118 (2020-06-20)
Nucleotide variants can cause functional changes by altering protein-RNA binding in various ways that are not easy to predict. This can affect processes such as splicing, nuclear shuttling, and stability of the transcript. Therefore, correct modeling of protein-RNA binding is
Giuseppe Militello et al.
Journal of molecular cell biology, 10(2), 102-117 (2018-04-05)
Myogenesis is a complex process required for skeletal muscle formation during embryonic development and for regeneration and growth of myofibers in adults. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) play key roles in regulating cell fate decision and function
View All Related Papers

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