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MilliporeSigma

EHU123221

MISSION® esiRNA

targeting human TP53

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324

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Product Name

MISSION® esiRNA, targeting human TP53

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

CATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGAGACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCCCCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGCTCCTCT

Ensembl | human accession no.

ENSG00000141510

NCBI accession no.

NM_000546

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

human ... TP53(7157), TP53(7157)

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MISSION® esiRNA targeting human TP53

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MISSION® esiRNA

MISSION® esiRNA targeting human TP53BP2

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EHU070471

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MISSION® esiRNA targeting human TP53BP1

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EHU156121

MISSION® esiRNA

MISSION® esiRNA targeting human PDGFRL

Sigma-Aldrich

EHU119531

MISSION® esiRNA

Gene Information

human ... TP53(7157), TP53(7157)

Gene Information

human ... TP53BP2(7159), TP53BP2(7159)

Gene Information

human ... TP53BP1(7158), TP53BP1(7158)

Gene Information

human ... PDGFRL(5157), PDGFRL(5157)

esiRNA cDNA target sequence

CATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGAGACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCCCCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGCTCCTCT

esiRNA cDNA target sequence

TCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAGTTCCTGGTACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAAGTGTGTAAGTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATGGAGGAAGGCTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGGGATTATGAACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAATGGTGGTGGGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGG

esiRNA cDNA target sequence

TCTCCAGACGCACAAAGAAAATCCTGTGTTGGATGTTGTGTCCAATCCTGAACAAACAGCTGGAGAAGAACGAGGAGACGGTAATAGTGGGTTCAATGAACATTTGAAAGAAAACAAGGTTGCAGACCCTGTGGATTCTTCTAACTTGGACACATGTGGTTCCATCAGTCAGGTCATTGAGCAGTTACCTCAGCCAAACAGGACAAGCAGTGTTCTGGGAATGTCAGTGGAATCTGCTCCTGCTGTGGAGGAAGAGAAGGGAGAAGAGTTGGAACAGAAGGAGAAAGAGAAGGAAGAAGATACTTCAGGCAATACTACACATTCCCTTGGTGCTGAAGATACTGCCTCATCACAGTTGGGTTTTGGGGTTCTGGAACTCTCCCAGAGCCAGGATGTTGAGGAA

esiRNA cDNA target sequence

GAATTCCCAGCCAAGGAGATCCCAGCCAATGGAACGGACATTGTTTATGACATGAAGCGGGGCTTTGTGTATCTGCAACCTCATTCCGAGCACCAGGGTGTGGTTTACTGCAGGGCGGAGGCCGGGGGCAGATCTCAGATCTCCGTCAAGTACCAGCTGCTCTATGTGGCGGTTCCCAGTGGCCCTCCCTCAACAACCATCTTGGCTTCTTCAAACAAAGTGAAAAGTGGGGACGACATCAGTGTGCTCTGCACTGTCCTGGGGGAGCCCGATGTGGAGGTGGAGTTCACCTGGATCTTCCCAGGGCAGAAGGATGAAAGGCCTGTGACGATCCAAGACACTTGGAGGTTGATCCACAGAGGACTGGGACACACCACGAGAATCTCCCAGAGTGTCATTACAGTGGAAGACTTTGAGACGATTGATGCAGG

Ensembl | human accession no.

ENSG00000141510

Ensembl | human accession no.

ENSG00000143514

Ensembl | human accession no.

ENSG00000067369

Ensembl | human accession no.

ENSG00000104213

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

NCBI accession no.

NM_000546

NCBI accession no.

NM_005426

NCBI accession no.

NM_001141980

NCBI accession no.

NM_006207

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yukihiro Furusawa et al.
Apoptosis : an international journal on programmed cell death, 22(10), 1225-1234 (2017-07-25)
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MicroRNAs (miRNAs) were involved in cancer progression, and the targeting of miRNAs by natural agents has opened avenues for cancer treatment and drug development. miR-16 functions as a tumor suppressor and is frequently deleted or downregulated in various human cancers
Mingyan Lin et al.
BMC systems biology, 10(1), 105-105 (2016-11-17)
Individuals with 22q11.2 Deletion Syndrome (22q11.2 DS) are a specific high-risk group for developing schizophrenia (SZ), schizoaffective disorder (SAD) and autism spectrum disorders (ASD). Several genes in the deleted region have been implicated in the development of SZ, e.g., PRODH
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Oncotarget, 7(49), 80450-80464 (2016-10-16)
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Identification of synthetically lethal cellular targets and synergistic drug combinations is important in cancer chemotherapy as they help to overcome treatment resistance and increase efficacy. The Ataxia Telangiectasia Mutated (ATM) kinase is a nuclear protein that plays a major role
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